Dopamine receptors in the striatum of rats exposed to repeated restraint stress and alprazolam treatment
Dopamine receptors in the striatum of rats exposed to repeated restraint stress and alprazolam treatment
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DOI：
10.1016/s0014-2999(97)01608-7
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发表时间：
1998-03-05
影响因子：
5
通讯作者：
Covelli, V
中科院分区：
文献类型：
--
作者：
Giardino, L;Zanni, M;Covelli, V
与压力相关的行为伴随着大脑中大量神经递质的改变。而且。与GABA（A）受体的结合不能解释苯并二氮杂卓类的所有作用。本文用受体定量放射自显影技术研究了反复束缚应激和阿普唑仑（1 mg/d，口服）对成年大鼠纹状体多巴胺受体（B-max和K-d）的影响。在慢性束缚应激后，多巴胺D-1受体（B-max值）在延髓核中降低，而多巴胺D-2受体在任何研究区域都没有改变。阿普唑仑治疗后，观察到纹状体中多巴胺D-1和D-2受体的显著增加。慢性固定应激与阿普唑仑治疗一起重新建立多巴胺D-1受体密度，以控制丘脑核和嗅结节中的值，而它导致与阿普唑仑单独治疗引起的增加相当的病态多巴胺D-2受体，（C）1998 Elsevier Science B. V.
Stress-related behaviors are accompanied by modification of a large number of neurotransmitters in the brain. Moreover. the binding to GABA(A) receptors does not account for all the effects of benzodiazepines. In this study we investigated the effect of repeated restraint stress and alprazolam treatment (1 mg/day os) on dopamine receptors: (B-max and K-d) in the striatum of adult rat by means of quantitative receptor autoradiography. After chronic restraint stress dopamine D-1 receptors (B-max value) decreased in the accumbens nucleus, whereas dopamine D-2 receptors were not modified in any investigated area. After alprazolam treatment, a considerable increase in both dopamine D-1 and D-2 receptors in the striatum was observed. Chronic immobilization stress together with alprazolam treatment re-established dopamine D-1 receptor density to control values in the accumbens nucleus and olfactory tubercle, whereas it resulted in an increase ill dopamine D-2 receptors comparable to that elicited by alprazolam treatment alone, (C) 1998 Elsevier Science B.V.