Estimation of Total Incremental Health Care Costs in Patients With Atrial Fibrillation in the United States
Estimation of Total Incremental Health Care Costs in Patients With Atrial Fibrillation in the United States
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DOI：
10.1161/circoutcomes.110.958165
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发表时间：
2011-05-01
影响因子：
6.9
通讯作者：
Schulman, Kathy L.
中科院分区：
文献类型：
--
作者：
Kim, Michael H.;Johnston, Stephen S.;Schulman, Kathy L.
背景——有关心房颤动 (AF) 费用负担的详细信息有限。为了提供全国 AF 成本的最新估计，我们使用 2004 年至 2006 年 MarketScan 商业和医疗保险补充研究数据库中的行政索赔进行了一项回顾性、观察性队列研究。方法和结果 - 年龄 >= 20 岁且 2005 年诊断出 >= 1 例住院患者或 >= 2 例门诊患者 AF 的患者（首次诊断 = 指数）且入组前 12 个月以上选择索引后。 AF 患者与非 AF 对照受试者进行倾向评分匹配 (1:1)。医疗费用（2008 美元），包括 AF 费用、其他心血管和非心血管费用，在指数发布一年多后进行了检查。全国 AF 增量成本基于 2010 年特定年龄/性别的 AF 患病率预测。总共有 89 066 名 AF 患者与非 AF 对照受试者相匹配。一年多以来，37.5% 的 AF 受试者住院治疗，而对照受试者为 17.5%，住院期间分别有 2.1% 和 0.1% 的受试者死亡。对于 AF 与对照受试者，每位患者的平均年度住院费用分别为 7841 美元与 2622 美元（增量成本为 5218 美元），门诊医疗费用分别为 9225 美元与 5629 美元（3596 美元），门诊药房费用分别为 3605 美元与 3714 美元（-109 美元）（所有 P
Background-Detailed information on the cost burden of atrial fibrillation (AF) is limited. To provide an up-to-date estimate of the national cost of AF, we conducted a retrospective, observational cohort study using administrative claims from the MarketScan Commercial and Medicare Supplemental research data bases, 2004 to 2006.Methods and Results-Patients aged >= 20 years with >= 1 inpatient or >= 2 outpatient AF diagnoses in 2005 (first diagnosis=index) and >= 12 months' enrollment before and after index were selected. AF patients were propensity score-matched (1: 1) with non-AF control subjects. Medical costs (2008 US$), including AF costs, other cardiovascular, and noncardiovascular costs, were examined over 1 year after index. National incremental costs of AF were based on age-/sex-specific AF prevalence projections for 2010. In total, 89 066 AF patients were matched to non-AF control subjects. Over 1 year, 37.5% of AF versus 17.5% of control subjects were hospitalized and 2.1% versus 0.1% died during hospitalization. For AF versus control subjects, mean annual inpatient costs per patient were $7841 versus $2622 (incremental cost, $5218), outpatient medical costs were $9225 versus $5629 ($3596), and outpatient pharmacy costs were $3605 versus $3714 (-$ 109) (all P