Hyperferritinemia is a potential marker of chronic chikungunya: A retrospective study on the Island of Curacao during the 2014-2015 outbreak
Hyperferritinemia is a potential marker of chronic chikungunya: A retrospective study on the Island of Curacao during the 2014-2015 outbreak
复制标题
DOI：
10.1016/j.jcv.2016.11.003
复制
发表时间：
2017-01-01
影响因子：
8.8
通讯作者：
Martina, Byron E. E.
中科院分区：
文献类型：
--
作者：
Anfasa, Fatih;Provacia, Lisette;Martina, Byron E. E.
背景：最近在加勒比地区报告了基孔肯雅病毒（CHIKV）暴发。没有关于库拉考疫情的数据。此外，迄今为止还没有生物标志物可用于预测慢性infection.Objectives：为了表征库拉考的第一次CHIKV爆发，并确定慢性infection.Study design的潜在生物标志物：血清学测试和定量聚合酶链反应（qPCR）被用于在库拉考收集的样本，以确认感染。随后，选择6个具有高病毒载量的样本进行系统发育分析。此外，我们研究了CHIKV感染期间巨噬细胞相关生物标志物与慢性关节痛/关节炎的关联。结果：库拉考的116名患者基于ELISA诊断为CHIKV感染，77%的患者通过qPCR检测为CHIKV阳性。系统发育分析表明，亚洲基因型是爆发的原因。铁蛋白和CRP水平升高与病毒血症显著相关。此外，铁蛋白水平升高与慢性arthritalges.Conclusions显着相关：结果表明，亚洲基因型的CHIKV在库拉考的第一次存在。此外，我们发现铁蛋白水平与慢性关节痛之间存在关联。(C)2016作者由Elsevier B. V.出版，这是CC BY-NC-ND许可下的开放获取文章。
Background: Recently Chikungunya virus (CHIKV) outbreaks have been reported in the Carribean. There is no data regarding the outbreak in Curacao. In addition, to date there is no biomarker that could be used to predict chronic infection.Objectives: To characterize the first CHIKV outbreak in Curacao and to identify potential biomarkers for chronic infection.Study design: A serological test and quantitative polymerase chain reaction (qPCR) were used on samples collected in Curacao to confirm infection. Subsequently, six samples with high viral load were selected for phylogenetic analysis. Furthermore we investigated the association of macrophage-related biomarkers during CHIKV infection with chronic arthralgia/arthritis.Results: 116 patients in Curacao were diagnosed with CHIKV infection based on ELISA and 77% were tested positive for CHIKV by qPCR. Phylogenetic analysis showed that an Asian genotype was the cause of the outbreak. Elevated levels of ferritin and CRP were significantly associated with viraemia. In addition, elevated ferritin levels were significantly associated with chronic arthralgia.Conclusions: The results showed that the presence of an Asian genotype of CHIKV in Curacao for the first time. Moreover, we found an association between ferritin levels with chronic arthralgia. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.