The Current Landscape of Immune Checkpoint Blockade in Glioblastoma
The Current Landscape of Immune Checkpoint Blockade in Glioblastoma
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DOI：
10.1016/j.nec.2020.12.003
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发表时间：
2021-03-26
影响因子：
2.6
通讯作者：
Reardon, David A.
中科院分区：
文献类型：
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作者：
Akintola, Oluwatosin O.;Reardon, David A.
？ 免疫检查点封锁已经彻底改变了许多实体恶性肿瘤的管理。？ 类似的阳性结果在免疫检查点阻断治疗胶质母细胞瘤中没有重复。？ 目前正在进行的研究进一步评估免疫检查点阻断在胶质母细胞瘤治疗中的潜在作用。？ 胶质母细胞瘤的多模式免疫治疗正在积极研究中，其结果有望指导免疫治疗在胶质母细胞瘤中的未来作用。？ 确定对免疫治疗反应的可靠生物标志物对opti至关重要
? Immune checkpoint blockade has revolutionized the management of many solid malignancies. ? Similar positive results have not been duplicated in the treatment of glioblastoma with immune checkpoint blockade. ? There are ongoing studies to further evaluate the potential role of immune checkpoint blockade in the management of glioblastoma. ? Multimodal immunotherapy for glioblastoma is under active investigation, and results are expected to direct the future role of immunotherapy in glioblastoma. ? Identification of reliable biomarkers of response to immunotherapy treatment is essential to opti