The Impact of Anogenital Warts on Health-Related Quality of Life: A 6-Month Prospective Study
The Impact of Anogenital Warts on Health-Related Quality of Life: A 6-Month Prospective Study
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DOI：
10.1097/olq.0b013e3182215512
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发表时间：
2011-10-01
影响因子：
3.1
通讯作者：
Mansi, James A.
中科院分区：
文献类型：
--
作者：
Drolet, Melanie;Brisson, Marc;Mansi, James A.
背景资料：肛门生殖器疣的负担将是决定使用人乳头瘤病毒（HPV）疫苗类型（二价或四价）以及是否接种男性的决定因素。我们进行了一项多中心的前瞻性研究，（1）描述肛门生殖器疣对生活质量的影响，（2）估计的质量调整生命年（QOLS）损失由于anogenitalwarts.Methods：2006年9月至2008年2月，272例首次或复发性肛门生殖器疣患者招募来自加拿大各地的42名医生的临床实践。在招募时以及2个月和6个月后使用EuroQol，Short Form-12，Short Spielberg State-Trait Anxiety Inventory和HPV影响概况测量生活质量。在发病后90天内招募的51例事件病例中，估计了一次发作的持续时间和由于肛门生殖器疣而导致的Q值损失。这种负面影响对于首次发作和复发发作是相似的，并且只要病变持续就持续。肛门生殖器疣对日常活动，疼痛/不适，焦虑/抑郁，自我形象，性活动和伴侣问题以及可能的传播产生最大的负面影响。中位持续时间的第一肛门生殖器疣发作之间的事件的情况下，是125天，导致Q值的损失为0.017至0.041，这相当于6至15天的健康生命losed.Conclusions：肛门生殖器疣的负担是巨大的，应该考虑由医生和公共卫生官员提出建议时，HPV疫苗接种。
Background: The burden of anogenital warts will be a determining factor when making decisions about the type of human papillomavirus (HPV) vaccine to be used (bivalent or quadrivalent) and whether to vaccinate males. We conducted a multicenter prospective study to (1) describe the impact of anogenital warts on quality of life and (2) estimate the quality-adjusted life-years (QALYs) lost due to anogenital warts.Methods: Between September 2006 and February 2008, 272 patients with a first or recurrent episode of anogenital warts were recruited from the clinical practices of 42 physicians across Canada. Quality of life was measured at recruitment, and 2 and 6 months later with the EuroQol, Short Form-12, short Spielberg State-Trait Anxiety Inventory, and HPV impact profile. The duration of an episode and QALYs lost due to anogenital warts were estimated among 51 incident cases recruited within 90 days of disease onset.Results: Anogenital warts had a significant impact on the quality of life. This negative impact was similar for first and recurrent episodes, and lasted as long as lesions persisted. Anogenital warts had the greatest negative impact on usual activities, pain/discomfort, and anxiety/depression, and on self-image, sexual activity, and partner issues and possible transmission. The median duration of a first anogenital wart episode amongst incident cases was 125 days and resulted in QALYs lost of 0.017 to 0.041, which is equivalent to 6 to 15 days of healthy life lost.Conclusions: The burden of anogenital warts is substantial and should be considered by physicians and public health officials when making recommendations about HPV vaccination.