A new role for Rab GTPases during early mitotic stages.
A new role for Rab GTPases during early mitotic stages.
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DOI：
10.4161/sgtp.29565
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Doxsey, Stephen
中科院分区：
文献类型：
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作者：
Das, Sanchaita;Hehnly, Heidi;Doxsey, Stephen
最近的一项研究揭示了Rab 11 GTdR在有丝分裂过程中的新作用。Rab 11通过动力蛋白介导的转运参与内体定位到有丝分裂纺锤体极的再循环。这一过程与高尔基体膜相反，高尔基体膜在有丝分裂中分散，似乎不直接参与有丝分裂功能。Rab 11的缺失阻止了纺锤体两极的内体组织再循环，延迟了有丝分裂进程，并破坏了纺锤体两极蛋白的募集、星形微管的组织和有丝分裂纺锤体的方向。然而，Rab 11不是唯一的内吞和/或运输蛋白，调节有丝分裂进程。网格蛋白和两个小的GTP酶（Rab 6A '，Rab 5）在纺锤体的组织和功能中起关键作用。在这篇评论中，我们讨论了所有这些典型的内吞和膜运输蛋白在有丝分裂过程中的作用，并推测它们之间可能的交叉通信和它们的分子途径，确保通过有丝分裂的忠实进展。
A recent study revealed new roles for the Rab11 GTPase during mitosis. Rab11 is involved in recycling endosome localization to mitotic spindle poles via dynein-mediated transport. This process is in contrast to Golgi membranes, which disperse in mitosis and do not appear to directly contribute to mitotic functions. Rab11-depletion prevents recycling endosome organization at spindle poles, delays mitotic progression, and disrupts spindle pole protein recruitment, astral microtubule organization, and mitotic spindle orientation. However, Rab11 is not the only endocytic and/or trafficking protein that regulates mitotic progression. Clathrin and two small GTPases (Rab6A', Rab5) play key roles in spindle organization and function. In this commentary, we discuss the roles of all these canonical endocytic and membrane trafficking proteins during mitosis and speculate on possible cross-communication between them and their molecular pathways that ensure faithful progression through mitosis.