SLEEP-DEPRIVATION IN RATS - EFFECTS ON EEG POWER SPECTRA, VIGILANCE STATES, AND CORTICAL TEMPERATURE
SLEEP-DEPRIVATION IN RATS - EFFECTS ON EEG POWER SPECTRA, VIGILANCE STATES, AND CORTICAL TEMPERATURE
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DOI：
10.1152/ajpregu.1991.261.1.r198
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发表时间：
1991-07-01
影响因子：
--
通讯作者：
BORBELY, AA
中科院分区：
文献类型：
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作者：
FRANKEN, P;DIJK, DJ;BORBELY, AA
10只大鼠在基线日、24 h睡眠剥夺（SD）期和2 d恢复（恢复1和恢复2）期间的警戒状态、脑电图（EEG）功率谱（0.25-25.0 Hz）和皮质温度（T(CRT)）。醒时脑电功率密度在SD期各频率均逐渐升高。非快速眼动睡眠（NREM）在两个恢复日都得到了加强，而快速眼动睡眠只在恢复日得到了加强。在恢复的最初4 h 1， NREM睡眠的脑电图慢波活动（SWA；平均功率密度0.75 ~ 4.0 Hz）相对于基线升高，短暂觉醒次数（nBA）减少。在恢复1的黑暗期和恢复2的光明期，SWA低于基线，nBA升高。在整个恢复期，SWA和nBA均以偏离基线值表示，呈负相关。在SD期间，T（CRT）高于基线，在恢复1的最初16 h低于基线。而T（CRT）与非快速眼动睡眠呈负相关，与非快速眼动睡眠的SWA无显著相关。由此得出的结论是，SD会导致短时间的睡眠强化，如SWA增强和nBA减少所示，而睡眠持续时间则会长期增加。SWA和TCRT的不同时间过程表明，NREM睡眠强度的变化与T（CRT）的变化没有直接关系。
Vigilance states, electroencephalogram (EEG) power spectra (0.25-25.0 Hz), and cortical temperature (T(CRT)) of 10 rats were obtained during a baseline day, a 24-h sleep deprivation (SD) period, and 2 days of recovery (recoveries 1 and 2). EEG power density in waking gradually increased in most frequencies during the SD period. Non-rapid-eye-movement (NREM) sleep was enhanced on both recovery days, and rapid-eye-movement sleep was enhanced only on recovery 1. In the initial 4 h of recovery 1, EEG slow-wave activity (SWA; mean power density 0.75-4.0 Hz) in NREM sleep was elevated relative to baseline, and the number of brief awakenings (nBA) was reduced. In the dark period of recovery 1 and the light period of recovery 2, SWA was below baseline, and nBA was increased. During the entire recovery period, SWA and nBA, both expressed as deviation from baseline values, were negatively correlated. During the SD period, T(CRT) was above baseline, and in the initial 16 h of recovery 1 it was below baseline. Whereas T(CRT) was negatively correlated with NREM sleep, no significant correlation was found between T(CRT) and SWA within NREM sleep. It is concluded that SD causes a short-lasting intensification of sleep, as indicated by the enhanced SWA and the reduced nBA, and a long-lasting increase in sleep duration. The different time courses of SWA and TCRT) suggest that variations in NREM sleep intensity are not directly related to changes in T(CRT).