Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease
Altered status of antioxidant vitamins and fatty acids in patients with inactive inflammatory bowel disease
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DOI：
10.1016/j.clnu.2008.01.007
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发表时间：
2008-08-01
影响因子：
6.3
通讯作者：
Lochs, Herbert
中科院分区：
文献类型：
--
作者：
Hengstermann, Susanne;Valentini, Luzia;Lochs, Herbert
背景与目的：关于非活动期IBD患者的营养状况、抗氧化剂和血浆脂肪酸(FA)组成的数据相互矛盾。方法：对132例静止期IBD患者(40.6±13.2岁，87F/45M)、35例活动期IBD患者(37.9±12.1岁，25F/10M)和45例健康对照(38.1+/-10.5年，39F/6M)的血浆维生素C、维生素E、类胡萝卜素、饱和、单不饱和和多不饱和脂肪酸水平、炎症标志物和营养状况进行了隔夜禁食测定。结果：非活动期(23.9±4.7)kg/m(2例)、活动期IBD(22.7±4.2 kg/m(2例))和对照组(22.3±1.9 kg/m(2例))体重指数(BMI)正常。与对照组相比，静止期IBD患者血浆类胡萝卜素(1.85[1.37；2.56]vs1.39[0.88；1.87]mU/L)和维生素C(62.3[48.7；75.0]vs51.0[36.4；77.6]mU/L)水平显著降低，饱和脂肪酸(3879[3380；]vs3410[3142；3989]mU/L)和单不饱和脂肪酸(2578[2258；3089]vs2044[1836；；Mu mol/L)和类似水平的维生素E和多不饱和脂肪酸。活动期疾病的结果与非活动期疾病的结果相似。结论：本研究表明，大多数IBD患者的抗氧化状态和FA谱独立于疾病活动而受到干扰，尽管总体营养状态正常。(C)2008年爱思唯尔有限公司和欧洲临床营养与代谢学会。版权所有。
Background & aims: Data regarding the nutritional status, antioxidant compounds and plasma fatty acid (FA) composition in inactive IBD are conflicting. We compared plasma levels of antioxidants and FA of patients with inactive IBD with active IBD and controls.Methods: Plasma levels of vitamin C, vitamin E, carotenoids, saturated, monounsaturated and polyunsaturated FA, inflammatory markers and nutritional status were determined after an overnight fast in 132 patients with quiescent IBD (40.6 +/- 13.2 years, 87F/45M), 35 patients with active disease (37.9 +/- 12.1 years, 25F/10M) and 45 age- and BMI-matched healthy controls (38.1 +/- 10.5 years, 39F/6M). Results are expressed as mean +/- SD or median [25th percentile;75th percentile].Results: Body mass index (BMI) was normal in inactive (23.9 +/- 4.7 kg/m(2)), active IBD (22.7 +/- 4.2 kg/m(2)) and controls (22.3 +/- 1.9kg/m(2)). Compared with controls patients with quiescent IBD showed significantly decreased plasma levels of carotenoids (1.85 [1.37;2.56] vs 1.39 [0.88;1.87] mu mol/L) and vitamin C (62.3 [48.7;75.0] vs 51.0 [36.4;77.6] mu mol/L), increased levels of saturated FA (3879 [3380;4420] vs 3410 [3142;3989] mu mol/L) and monounsaturated FA (2578 [2258;3089] vs 2044 [1836;2434] mu mol/ L) and similar levels of vitamin E and polyunsaturated FA. Results in active disease were similar to inactive disease.Conclusion: This study shows that antioxidant status and FA profile in a larger population of IBD patients are disturbed independently from disease activity and despite normal overall nutritional status. (C) 2008 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.