Whole-body utilization of n-3 PUFA in n-6 PUFA-deficient rats
Whole-body utilization of n-3 PUFA in n-6 PUFA-deficient rats
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DOI：
10.1007/s11745-003-1050-8
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发表时间：
2003-02-01
期刊：
影响因子：
1.9
通讯作者：
Cunnane, SC
中科院分区：
文献类型：
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作者：
Bazinet, RP;Douglas, H;Cunnane, SC
我们评估了α-亚麻酸(18：3n-3)在食用n-6多不饱和脂肪酸缺乏的饲料中的利用情况。90d后，n-6PUFA缺乏大鼠的全身18：3n-3蓄积量降低55%，n-3PUFA总蓄积量减少21%，18：3n-3消失率增加14%。N-6多不饱和脂肪酸缺乏大鼠全身18：3n-3的降低部分是由于18：3n-3向长链n-3多不饱和脂肪酸的净转化率增加了25%。尽管18：3n-3摄入量充足，但n-6PUFA缺乏降低了18：3n-3和总n-3PUFA的积累量。
We evaluated the utilization of alpha-linolenic acid (18:3n-3) in growing rats consuming a diet deficient in n-6 PUFA. After 90 d, whole-body 18:3n-3 accumulation was 55% lower, total n-3 PUFA accumulation was 21% lower, and 18:3n-3 disappearance was 14% higher in n-6 PUFA-deficient rats. Part of the reduction of whole-body 18:3n-3 in n-6 PUFA-deficient rats was due to the 25% increase in net conversion of 18:3n-3 to long-chain n-3 PUFA. Despite adequate 18:3n-3 intake, n-6 PUFA deficiency decreased the accumulation of 18:3n-3 and total n-3 PUFA.