Autoimmune disease associated IFIH1 single nucleotide polymorphism related with IL-18 serum levels in Chinese systemic lupus erythematosus patients.
Autoimmune disease associated IFIH1 single nucleotide polymorphism related with IL-18 serum levels in Chinese systemic lupus erythematosus patients.
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中国系统性红斑狼疮患者自身免疫性疾病相关IFIH1单核苷酸多态性与血清IL-18水平的关系
DOI：
10.1038/s41598-018-27782-7
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发表时间：
2018-06-21
影响因子：
4.6
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Zhang J;Liu X;Meng Y;Wu H;Wu Y;Yang B;Wang L
Systemic lupus erythematosus (SLE) has heterogeneous clinical manifestations. IFIH1 (interferon induced with helicase C domain 1) as one of antiviral helicase genes mediating type I interferon production, plays an essential role in the pathogenesis of SLE. The gene variants in IFIH1 could abnormally activate antiviral defenses and increased type I interferon signaling. The present study aimed to validate associations between single nucleotide polymorphisms (SNP) in IFIH1 and the pathogenesis of SLE. In total, rs1990760, rs3747517 and rs10930046 in IFIH1 are genotyped in 400 SLE patients and 659 health controls in Chinese cohort by an improved multiplex ligation detection reaction (iMLDR) technique. Significant associations were observed between alleles of IFIH1 (rs1990760 C > T, P = 0.005, OR = 1.36, 95%CI = 1.10–1.69; rs3747517 T > C, P = 0.004, OR = 1.31, 95%CI = 1.09–1.58, respectively) and SLE susceptibility. IFIH1 rs1990760 TT genotype carriers had lower serum levels of IL-18 (P < 0.001) and granzyme B (P < 0.001) than CC and CT genotype carriers. IFIH1 rs1990760 CT genotype carriers had higher anti-dsDNA–positive than CC and TT genotype carriers. In conclusion, IFIH1 polymorphisms (rs1990760 and rs3747517) were associated with SLE susceptibility and rs1990760 risk T allele related with IL-18 and granzyme B serum levels in SLE patients.
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影响因子：
4.5
作者：
Cunninghame Graham DS;Morris DL;Bhangale TR;Criswell LA;Syvänen AC;Rönnblom L;Behrens TW;Graham RR;Vyse TJ
通讯作者：
Vyse TJ
影响因子：
4
作者：
Enevold, C.;Kjaer, L.;Jacobsen, S.
通讯作者：
Jacobsen, S.
影响因子：
5.1
作者：
Kahlenberg JM;Kaplan MJ
通讯作者：
Kaplan MJ
影响因子：
4.5
作者：
Molineros JE;Maiti AK;Sun C;Looger LL;Han S;Kim-Howard X;Glenn S;Adler A;Kelly JA;Niewold TB;Gilkeson GS;Brown EE;Alarcón GS;Edberg JC;Petri M;Ramsey-Goldman R;Reveille JD;Vilá LM;Freedman BI;Tsao BP;Criswell LA;Jacob CO;Moore JH;Vyse TJ;Langefeld CL;Guthridge JM;Gaffney PM;Moser KL;Scofield RH;Alarcón-Riquelme ME;BIOLUPUS Network;Williams SM;Merrill JT;James JA;Kaufman KM;Kimberly RP;Harley JB;Nath SK
通讯作者：
Nath SK
IL-18R和DR3的T细胞表达对于非认知刺激Th1细胞和最佳清除细胞内细菌至关重要。
影响因子：
6.7
作者：
Pham OH;O'Donnell H;Al-Shamkhani A;Kerrinnes T;Tsolis RM;McSorley SJ
通讯作者：
McSorley SJ