Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).
Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).
复制标题
DOI：
10.1016/j.it.2009.09.007
复制
发表时间：
2010-01
影响因子：
16.8
通讯作者：
Jope RS
中科院分区：
文献类型：
--
作者：
Beurel E;Michalek SM;Jope RS
在短短几年内，糖原合成酶激酶-3(GSK3)已经从免疫文献中很少遇到的一个鲜为人知的酶变成了一个与大量作用有关的不可思议的酶。GSK3是外周和中枢神经系统中促炎和抗炎细胞因子产生之间平衡的关键调节因子，赋予GSK3抑制剂如锂的抗炎能力。GSK3影响T细胞的增殖、分化和存活。许多效应源于Gsk3对关键转录因子的调节，如NF-κB、NFAT和STATS。这些发现导致GSK3抑制剂迅速应用于脓毒症、关节炎、结肠炎、多发性硬化症和其他动物模型，证明了它们具有治疗干预的潜力。
In just a few years, glycogen synthase kinase-3 (GSK3) has transformed from an obscure enzyme seldom encountered in the immune literature to one implicated in an improbably large number of roles. GSK3 is a crucial regulator of the balance between pro- and anti-inflammatory cytokine production in both the periphery and the central nervous system, endowing GSK3 inhibitors such as lithium with the capacity to diminish inflammation. T cell proliferation, differentiation, and survival are influenced by GSK3. Many effects stem from GSK3 regulation of critical transcription factors, such as NF-κB, NFAT and STATs. These discoveries led to the rapid application of GSK3 inhibitors to animal models of sepsis, arthritis, colitis, multiple sclerosis, and others that demonstrated their potential for therapeutic interventions.
登录
查看更多内容
DOI：
10.4049/jimmunol.181.1.338
发表时间：
2008-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
De Sarno P;Axtell RC;Raman C;Roth KA;Alessi DR;Jope RS
通讯作者：
Jope RS
影响因子：
4.8
作者：
Beurel, Eleonore;Jope, Richard S.
通讯作者：
Jope, Richard S.
DOI：
10.1016/j.biocel.2005.06.002
发表时间：
2005-10-01
影响因子：
4
作者：
Evenson, AR;Fareed, MU;Hasselgren, PO
通讯作者：
Hasselgren, PO
影响因子：
7.7
作者：
Collino, Massimo;Aragno, Manuela;Castiglia, Sara;Tomasinelli, Chiara;Thiemermann, Christoph;Boccuzzi, Giuseppe;Fantozzi, Roberto
通讯作者：
Fantozzi, Roberto
影响因子：
9.3
作者：
Beurel E;Jope RS
通讯作者：
Jope RS