Spread of OXA-48-Encoding Plasmid in Turkey and Beyond
Spread of OXA-48-Encoding Plasmid in Turkey and Beyond
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DOI：
10.1128/aac.01312-09
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发表时间：
2010-03-01
影响因子：
4.9
通讯作者：
Nordmann, Patrice
中科院分区：
文献类型：
--
作者：
Carrer, Amelie;Poirel, Laurent;Nordmann, Patrice
对从土耳其、黎巴嫩、埃及、法国和比利时回收的 18 种碳青霉烯类耐药、OXA-48 阳性肠杆菌分离株进行了分析。在大多数分离株中，鉴定出类似的携带碳青霉烯酶基因 bla(OXA-48) 的 70 kb 质粒。该基因位于转座子 Tn1999 或转座子 Tn1999.2 内，而转座子 Tn1999.2 始终插入同一基因内。这项工作强调了目前 OXA-48 碳青霉烯酶在全球范围内通过质粒介导的传播。
Eighteen carbapenem-resistant, OXA-48-positive enterobacterial isolates recovered from Turkey, Lebanon, Egypt, France, and Belgium were analyzed. In most isolates, similar 70-kb plasmids carrying the carbapenemase gene bla(OXA-48) were identified. That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide.