Light-actuated high pressure-resisting microvalve for on-chip flow control based on thermo-responsive nanostructured polymer
Light-actuated high pressure-resisting microvalve for on-chip flow control based on thermo-responsive nanostructured polymer
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DOI：
10.1039/b803293a
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发表时间：
2008-01-01
期刊：
影响因子：
6.1
通讯作者：
Knapp, Daniel R.
中科院分区：
文献类型：
--
作者：
Chen, Guofang;Svec, Frantisek;Knapp, Daniel R.
介绍了一种简单的光驱动微阀，该微阀采用石英卤素灯和钨丝作为光源，可有效地控制微全分析系统中的流路，降低了系统的复杂性和片上集成的需求。环烯烃共聚物（COC）微芯片中的微阀器件基于温敏聚合物聚（N-异丙基丙烯酰胺）（PNIPAAm），其耐压性可以通过选择合适的单体和交联剂量来改变微通道内聚合物整体的机械强度来调节。阀的响应时间和耐压性也可以通过聚合混合物中的四氢呋喃组合物来优化。非常重要的是，该微型阀可以承受高达1350 psi左右的泄漏压力，其开启和关闭响应时间分别仅为4.0和6.2 s。具有这种阀门的微芯片在药物输送、化学分析和蛋白质组学分析方面将非常有用。
A simple light-actuated microvalve using a quartz halogen illuminator with tungsten filament was introduced to manipulate flow path effectively in micro-total analysis systems, which reduces system complexity and the need for on-chip integration. The microvalve device in cyclic olefin copolymer (COC) microchip functions very well based on the thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), whose pressure-tolerance can be tuned by changing the mechanical strength of polymer monolith inside the microchannel with the choice of suitable amount of monomer and crosslinker. The response time and pressure resistance of the valve can be optimized by the tetrahydrofuran composition in the polymerization mixture as well. Very importantly, the microvalve can withstand the leakage pressure up to around 1350 psi, and its opening and closing response time is only 4.0 and 6.2 s respectively. Microchips with such valves will be very useful in drug delivery, chemical analysis and proteomic analysis.