Association between myopia and complications of glaucoma with retinal diseases: investigation of a large medical insurance database. Graefes
Association between myopia and complications of glaucoma with retinal diseases: investigation of a large medical insurance database. Graefes
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近视与青光眼视网膜疾病并发症之间的关联：大型医疗保险数据库的调查。
DOI：
10.1007/s00417-023-06031-2
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Nakazawa T.
中科院分区：
文献类型：
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作者：
Ninomiya T;Kunikata H;Ishikawa M;Nakazawa T.
青光眼是导致不可逆失明的主要原因之一，并显著增加了社会和经济负担。其他导致失明的主要视网膜原因包括年龄相关性黄斑变性（AMD）和糖尿病视网膜病变（DR）。视网膜前膜（ERM）和黄斑裂孔（MH）不太可能导致失明，但患病率很高。因此，患有这些视网膜疾病中的任何一种的眼睛中的青光眼并发症是严重的问题。因此，迫切需要评估患有视网膜疾病和青光眼的眼睛的患病率，并澄清这种相互作用是否也与近视有关，近视是另一个严重的全球性临床问题。在这项研究中，我们研究了来自医疗保险数据库的大型数据集;该数据库包含15284只青光眼、3899只ERM、1167只MH、3474只AMD、3906只非增殖性糖尿病视网膜病变（NPDR）和2160只增殖性糖尿病视网膜病变（PDR）的记录（表1）。我们的研究包括各种青光眼亚型，如开角型、闭角型、正常眼压型和继发性青光眼（表1脚注），但不包括高眼压症。我们确定了视网膜疾病并发青光眼的比率，我们还确定了相反的比率，即青光眼并发视网膜疾病的比率。最后，我们调查了这些并发症的发生率与屈光不正的关系。表1总结了我们的发现，并显示了组间比较的P值。青光眼合并ERM、MH、AMD和PDR的发生率分别为5.1%、0.6%、2.3%和3.2%（P< 0.01）。相反，患有ERM、MH、AMD、NPDR和PDR的眼睛并发青光眼的比率为20.0%，
Dear Editor, Glaucoma is one of the leading causes of irreversible blindness and significantly increases social and economic burdens. Other leading retinal causes of blindness include age-related macular degeneration (AMD) and diabetic retinopathy (DR). Epiretinal membrane (ERM) and macular hole (MH) are less likely to cause blindness but have a very high prevalence. Thus, complication with glaucoma in eyes with any of these retinal diseases is a severe problem. Therefore, there is a pressing need to evaluate the prevalence of eyes with both retinal disease and glaucoma and to clarify whether this interaction is also associated with myopia, another serious worldwide clinical problem. In this study, we investigated a large data set derived from a medical insurance database; this database contained the records of 15284 eyes with glaucoma, 3899 eyes with ERM, 1167 eyes with MH, 3474 eyes with AMD, 3906 eyes with non-proliferative diabetic retinopathy (NPDR), and 2160 eyes with proliferative diabetic retinopathy (PDR)(Table 1). Our study included various subtypes of glaucoma, such as open-angle, angle-closure, normal-tension, and secondary glaucoma (Table 1 footnote), but not ocular hypertension. We determined the rate at which the retinal diseases were complicated with glaucoma, and we also determined the inverse, ie, the rate at which glaucoma was complicated with retinal diseases. Finally, we investigated the association of each of these rates of complication with refractive error. Table 1 summarizes our findings and shows the P values of an inter-group comparison. Eyes with glaucoma had complication with ERM, MH, AMD, and PDR at rates of 5.1%, 0.6%, 2.3%, and 3.2%, respectively (P< 0.01). Conversely, eyes with ERM, MH, AMD, NPDR, and PDR had complication with glaucoma at rates of 20.0%,