The MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validity
The MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validity
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DOI：
10.1176/appi.ajp.2007.07010042
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发表时间：
2008-02-01
影响因子：
17.7
通讯作者：
Marder, Stephen R.
中科院分区：
文献类型：
--
作者：
Nuechterlein, Keith H.;Green, Michael F.;Marder, Stephen R.
目的：缺乏一个公认的标准来衡量精神分裂症的认知变化一直是监管批准认知增强治疗的主要障碍。国家精神卫生研究所的测量和治疗研究，以改善认知精神分裂症（MATRICS）倡议的主要任务是通过广泛的科学评估措施，为精神分裂症认知增强治疗的临床试验开发共识认知电池。方法：MATRICS神经认知委员会评估了七个认知领域的90多个测试，以确定36个最有前途的措施。一个独立的专家小组评估了每个测试符合特定选择标准的程度。选择20项测试作为测试组合。测试电池被管理到176个人与精神分裂症和rereadinaires到167人4周后，使20个测试可以比较directly.Results：专家小组的评级为最初选择的36个测试。对于β组合测试，重测信度，实践效果，功能状态的关系，实用性和耐受性的数据。基于这些数据，10个测试被选中代表七个认知领域的MATRICS共识认知battery.Conclusions：结构化的共识方法是一个可行的和公平的机制，用于选择候选测试，和直接比较β电池测试在一个共同的样本允许选择最终的共识电池。MATRICS共识认知成套测验有望成为精神分裂症认知增强药物临床试验中评估认知变化的标准工具。它还可以帮助评估认知补救策略。
Objective: The lack of an accepted standard for measuring cognitive change in schizophrenia has been a major obstacle to regulatory approval of cognition-enhancing treatments. A primary mandate of the National institute of Mental Health's Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative was to develop a consensus cognitive battery for clinical trials of cognition-enhancing treatments for schizophrenia through a broadly based scientific evaluation of measures.Method: The MATRICS Neurocognition Committee evaluated more than 90 tests in seven cognitive domains to identify the 36 most promising measures. A separate expert panel evaluated the degree to which each test met specific selection criteria. Twenty tests were selected as a beta battery. The beta battery was administered to 176 individuals with schizophrenia and readministered to 167 of them 4 weeks later so that the 20 tests could be compared directly.Results: The expert panel ratings are presented for the initially selected 36 tests. For the beta battery tests, data on test-retest reliability, practice effects, relationships to functional status, practicality, and tolerability are presented. Based on these data, 10 tests were selected to represent seven cognitive domains in the MATRICS Consensus Cognitive Battery.Conclusions: The structured consensus method was a feasible and fair mechanism for choosing candidate tests, and direct comparison of beta battery tests in a common sample allowed selection of a final consensus battery. The MATRICS Consensus Cognitive Battery is expected to be the standard tool for assessing cognitive change in clinical trials of cognition-enhancing drugs for schizophrenia. it may also aid evaluation of cognitive remediation strategies.