Cross-Modal Functional Reorganization of Visual and Auditory Cortex in Adult Cochlear Implant Users Identified with fNIRS
Cross-Modal Functional Reorganization of Visual and Auditory Cortex in Adult Cochlear Implant Users Identified with fNIRS
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DOI：
10.1155/2016/4382656
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发表时间：
2016-01-01
影响因子：
3.1
通讯作者：
Debener, Stefan
中科院分区：
文献类型：
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作者：
Chen, Ling-Chia;Sandmann, Pascale;Debener, Stefan
与正常听力(NH)对照组相比，植入人工耳蜗(CI)的受试者在视觉皮质中表现出更高的听觉诱发激活，在听觉皮质中表现出更高的视觉诱发激活，这反映了视觉和听觉模式的功能重组。听觉皮层的视觉诱发激活是一种不适应的功能重组，而视觉皮层的听觉诱发激活有利于CI使用者的语音识别。我们用功能性近红外光谱(FNIRS)对20名语后聋CI患者和20名NH对照进行了测试，研究了它们对CI用户语音识别的联合影响。当呈现视觉棋盘和听觉单词刺激时，视标被放置在枕区和颞区以测量视觉和听觉反应。与NH对照组相比，CI组的听觉和视觉皮质均有更高的跨模式激活，这表明fNIRS可以识别听觉和视觉皮质的功能重组。此外，听觉和视觉皮质的联合重组被发现与语音识别性能有关。只要视觉皮层中有益的听觉诱发激活高于听觉皮质中的视觉诱发激活，就可以获得良好的言语表现。这些结果表明，考虑视觉和听觉皮质的跨模式激活对于潜在的临床结果估计是重要的。
Cochlear implant (CI) users show higher auditory-evoked activations in visual cortex and higher visual-evoked activation in auditory cortex compared to normal hearing (NH) controls, reflecting functional reorganization of both visual and auditory modalities. Visual-evoked activation in auditory cortex is a maladaptive functional reorganization whereas auditory-evoked activation in visual cortex is beneficial for speech recognition in CI users. We investigated their joint influence on CI users' speech recognition, by testing 20 postlingually deafened CI users and 20 NH controls with functional near-infrared spectroscopy (fNIRS). Optodes were placed over occipital and temporal areas to measure visual and auditory responses when presenting visual checkerboard and auditory word stimuli. Higher cross-modal activations were confirmed in both auditory and visual cortex for CI users compared to NH controls, demonstrating that functional reorganization of both auditory and visual cortex can be identified with fNIRS. Additionally, the combined reorganization of auditory and visual cortex was found to be associated with speech recognition performance. Speech performance was good as long as the beneficial auditory-evoked activation in visual cortex was higher than the visual-evoked activation in the auditory cortex. These results indicate the importance of considering cross-modal activations in both visual and auditory cortex for potential clinical outcome estimation.