Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum
Crystal structure of an NPNA-repeat motif from the circumsporozoite protein of the malaria parasite Plasmodium falciparum
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DOI：
10.1039/b510812h
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发表时间：
2006-01-01
影响因子：
4.9
通讯作者：
Robinson, JA
中科院分区：
文献类型：
--
作者：
Ghasparian, A;Moehle, K;Robinson, JA
据报道，肽Ac-Ala-Asn-ProAsn- Ala-NH2的晶体结构，代表疟疾寄生虫的主要表面蛋白的免疫优势区；NPNA基序采用i型β -turn，通过Asn(2)的CO与Ala(5)的NH之间以及Asn(2)的O（δ）与Asn(4)的NH之间的氢键来稳定NPNA基序。
A crystal structure is reported of the peptide Ac-Ala-Asn-ProAsn- Ala-NH2, representing the immunodominant region of the major surface protein on the malaria parasite; the NPNA motif adopts a type-I beta-turn, which is stabilized by hydrogen bonding between the CO of Asn(2) and the NH of Ala(5) as well as between the O(delta) of Asn(2) and the NH of Asn(4).