CRYOTHERAPY CAUSES EXTENSIVE BREAKDOWN OF THE BLOOD-RETINAL BARRIER - A COMPARISON WITH ARGON-LASER PHOTOCOAGULATION
CRYOTHERAPY CAUSES EXTENSIVE BREAKDOWN OF THE BLOOD-RETINAL BARRIER - A COMPARISON WITH ARGON-LASER PHOTOCOAGULATION
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DOI：
10.1001/archopht.1985.01050110124039
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发表时间：
1985-01-01
影响因子：
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通讯作者：
CAMPOCHIARO, PA
中科院分区：
文献类型：
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作者：
JACCOMA, EH;CONWAY, BP;CAMPOCHIARO, PA
使用计算机化玻璃体荧光光度法（VFP）在有色兔，我们检查了两种方式经常用于视网膜复位手术，冷冻和氩激光光凝，其对血视网膜屏障的影响。静脉注射14 mg/kg荧光素钠后1小时，在透镜后2 mm处读取VFP读数。在基线荧光光度测量读数后，在下方180度范围内对兔子进行融合冷冻治疗。在一只眼睛中，在另一只眼睛中，在视网膜的等效区域上使用汇合激光。在治疗后2、4、6和15天进行VFP读数。到第6天，VFP阅读已从治疗前的6.4 ± 1升高。0.4 ng/mL至41.8 ±. 7.9 ng/mL，而不是15.5 ±。3.1 ng/mL。到第15天，读数几乎回到基线，两个治疗组之间没有显著差异。这些数据表明，有一个显着的破坏血视网膜屏障与这两种方式，但它是相当严重的冷冻治疗。
Using computerized vitreous fluorophotometry (VFP) in pigmented rabbits, we examined two modalities frequently used in retinal reattachment surgery, cryotherapy and argon laser photocoagulation, for their effect on the blood-retinal barrier. The VFP readings were taken 2 mm posterior to the lens one hour after intravenous injection of 14 mg/kg of fluorescein sodium. After baseline fluorophotometry readings, rabbits were treated with confluent crytotherapy over the inferior 180.degree. in one eye and with confluent laser over an equivalent area of retina in the other eye. The VFP readings were taken 2,4,6, and 15 days after treatment. By day 6, the VFP reading had risen from a pretreatment value of 6.4 .+-. 0.4 ng/mL to 41.8 .+-. 7.9 ng/mL in the cryotherapy-treated eyes as opposed to 15.5 .+-. 3.1 ng/mL in the laser-treated eyes. By day 15, the readings were almost back to baseline, and there was no significant difference between the two treatment groups. These data suggest that there is a significant breakdown of the blood-retinal barrier with both modalities, but that it is considerably more severe with cryotherapy.