THE PRINCIPLES OF NORMAL AND ABNORMAL HINDGUT DEVELOPMENT
THE PRINCIPLES OF NORMAL AND ABNORMAL HINDGUT DEVELOPMENT
复制标题
DOI：
10.1016/0022-3468(95)90007-1
复制
发表时间：
1995-08-01
影响因子：
2.4
通讯作者：
LAMBRECHT, W
中科院分区：
文献类型：
--
作者：
KLUTH, D;HILLEN, M;LAMBRECHT, W
在过去，已经提出了几种理论来解释肛门直肠畸形的发生。大多数研究人员认为，这些畸形是隔膜受损的结果。然而，1986年，vd普特挑战了所有试图通过泄殖腔侧脊的错误融合来解释肛门直肠畸形的理论。为了阐明泄殖腔发育正常和异常的原理，作者研究了正常大鼠胚胎和经常出现泄殖腔异常的SD小鼠胚胎的这一区域的形态。用扫描电子显微镜观察了245个正常大鼠胚胎和80个异常SD小鼠胚胎。研究结果如下：(1)在正常胚胎中，在泄殖腔膜建立后不久，就可以识别未来肛门开口的区域。这部分是泄殖腔发育中的一个固定点。(2)畸形胚胎泄殖腔膜过短。未来肛门开口的区域缺失。(3)在畸形胚胎中可观察到畸形泄殖腔。这与临床上观察到的人类肛门直肠畸形的频谱是一致的。(4)作者的观察支持了最近的发现，即肛门直肠畸形的“瘘管”类似于异位的正常肛门。版权所有(C)1995，由W.B.Saunders公司
In the past, several theories have been proposed to explain the occurrence of anorectal malformations. Most investigators believe that these malformations are the result of an impaired process of septation. However, in 1986 vd Putte challenged all theories that tried to explain anorectal malformations by a faulty fusion of lateral ridges of the cloaca. To elucidate the principles of normal and abnormal cloacal development, the authors studied the morphology of this region in normal embryos of rats and abnormal embryos of SD mice, which often have abnormal cloacas. Using scanning electron microscopy (SEM), 245 normal rat embryos and 80 abnormal SD-mice embryos were observed. The results were as follows. (1) In normal embryos the region of the future anal opening can be identified soon after the establishment of the cloacal membrane. This part is a fixed point in cloacal development. (2) In abnormal embryos the cloacal membrane is too short. The region of the future anal opening is missing. (3) In abnormal embryos a spectrum of malformed cloacas can be observed. This is in accordance with the spectrum of anorectal malformations clinically observed in humans. (4) The authors' observations support recent findings that the ''fistula'' in anorectal malformations resembles a normal anus at an ectopic position. Copyright (C) 1995 by W.B. Saunders Company