REPRODUCTIVE EFFECTS OF HERBICIDE EXPOSURE IN VIETNAM - RECENT STUDIES BY THE VIETNAMESE AND OTHERS
REPRODUCTIVE EFFECTS OF HERBICIDE EXPOSURE IN VIETNAM - RECENT STUDIES BY THE VIETNAMESE AND OTHERS
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DOI：
10.1002/tcm.1770050404
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
HATCH, MC
中科院分区：
文献类型：
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作者：
CONSTABLE, JD;HATCH, MC
接触除草剂如橙剂及其污染物2，3，7，8-四氯二苯并-对二恶英的儿童是否有不良影响？在美国和其他地方，在法院和科学会议上，这个重要的问题仍在继续辩论。最初，实验室中的观察结果引发了对暴露人群可能受到伤害的担忧：具体地说，接受治疗的雌性动物的后代中的致畸效应，以及接受治疗的雄性动物的一些睾丸毒性。从实验数据中也可以明显看出，不同物种(小型哺乳动物、非人类灵长类)的反应差异很大。因此，来自人类研究的直接证据显然是回答有关人类生殖风险的问题所必需的。令人遗憾的是，这样的数据很少，而且质量往往很差。1 4用于文献的批判性评论]。关于在越南服役的美国士兵生育结果的两项相关研究最近发表了15-71篇。我们将在下面简要讨论这些最新报告，但任何希望进一步阅读和评估它们的人当然都可以使用它们。这篇文章的主要目的是向感兴趣的读者尽可能全面地介绍越南研究人员进行的相关但未发表的流行病学调查。这些研究不太可能在西方科学期刊上发表，于1983年1月在胡志明市(前西贡)举行的关于苯氧基除草剂长期影响的国际研讨会上发表，作者与来自美国、英国、西欧和东欧、亚洲和苏联的约70名来访科学家一起出席了会议。由于持续的辩论，我们似乎有必要让这些研究引起更广泛的科学界的注意，并提供
Are there adverse effects on the children of individuals exposed to such herbicides as Agent Orange and its contaminant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin? This weighty question continues to be debated here in the United States and elsewhere, in the courts as well as in scientific meetings. Initially, concern about possible harm to exposed human populations was prompted by observations in the laboratory: specifically, teratogenic effects among the offspring of treated females and some testicular toxicity in treated males. From the experimental data it was also apparent that the variation in response across species (small mammals, nonhuman primates) was considerable. Hence direct evidence from studies in man is clearly essential to answer questions about the reproductive risk to humans. Regrettably, such data are sparse and frequently poor in quality.[see refs. 1 4 for critical reviews of the literature]. Two relevant studies of reproductive outcomes among US soldiers serving in Vietnam have recently been published 15-71. We discuss these latest reports briefly below, but they are of course available to anyone wishing to peruse and evaluate them further. The principal objective of this paper is to put before the interested reader as full an account as possible of related but unpublished epidemiologic investigations carried out by Vietnamese researchers. These studies, which are unlikely ever to appear in Western scientific journals, were presented in January 1983 at an International Symposium on the long-term effects of phenoxy herbicides, held in Ho Chi Minh City (formerly Saigon) and attended by the authors along with some 70 other visiting scientists from the US, the United Kingdom, Western and Eastern Europe, Asia, and the USSR Because of the continuing debate, it seemed to us important to bring these studies to the attention of the wider scientific community and to provide as