Radioimmunotherapeutic approaches for leukemia: the past, present and future.
Radioimmunotherapeutic approaches for leukemia: the past, present and future.
复制标题
白血病的放射免疫治疗方法:过去、现在和未来。
DOI:
10.1080/14653240701679881
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发表时间:
2008
期刊:
影响因子:
4.5
通讯作者:
Pagel,JM
中科院分区:
文献类型:
--
作者:
Pagel,JM
For more than a decade, Ab conjugated to a radionuclide emitting particulate radiation has been used in the management of leukemia in an effort to deliver targeted doses of radiation to BM, spleen and other sites of disease, while sparing normal organs. This radioimmunotherapy (RIT) approach has been employed to achieve significant remissions in patients with AML, particularly when used at high doses of radioactivity in conjunction with myeloablation. This report focuses on the therapeutic aspects of radiolabeled Ab for leukemia. Clinical results from recent leukemia RIT studies are reviewed, with emphasis on approaches being evaluated to improve rates of response and survival. Discussion of pre-clinical studies are limited to those that offer insights into future directions for clinical RIT studies of leukemia.
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影响因子:
9.3
作者:
D. Mulford;D. Scheinberg;J. Jurcic
通讯作者:
J. Jurcic
影响因子:
8.8
作者:
A. Noworolska;A. Harłozińska;R. Richter;W. Brodzka
通讯作者:
W. Brodzka
影响因子:
20.3
作者:
Matthews, DC;Appelbaum, FR;Bernstein, ID
通讯作者:
Bernstein, ID
DOI:
10.1200/jco.1993.11.2.294
发表时间:
1993
期刊:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子:
--
作者:
Schwartz,MA;Lovett,DR;Redner,A;Finn,RD;Graham,MC;Divgi,CR;Dantis,L;Gee,TS;Andreeff,M;Old,LJ
通讯作者:
Old,LJ
DOI:
--
发表时间:
1995
期刊:
Cancer research.
影响因子:
--
作者:
Jurcic,JG;Caron,PC;Nikula,TK;Papadopoulos,EB;Finn,RD;Gansow,OA;MillerJr,WH;Geerlings,MW;WarrellJr,RP;Larson,SM
通讯作者:
Larson,SM