Associations Between Outer Retinal Structures and Focal Macular Electroretinograms in Patients With Retinitis Pigmentosa.
Associations Between Outer Retinal Structures and Focal Macular Electroretinograms in Patients With Retinitis Pigmentosa.
复制标题
色素性视网膜炎患者的外视网膜结构与局灶性黄斑视网膜电图之间的关联。
DOI：
10.1167/iovs.17-22040
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Terasaki H.
中科院分区：
文献类型：
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作者：
Kominami T;Ueno S;Kominami A;Nakanishi A;Yasuda S;Piao CH;Okado S;Terasaki H.
目的：我们早期的研究表明，光感受器完整椭圆区（EZ）的宽度与黄斑部视网膜电图（FMERG）的振幅有显著但微弱的相关性。本研究的目的是确定光谱域光学相干断层扫描（SD-OCT）图像中的光感受器的微观结构，该图像与视网膜色素变性（RP）眼睛中的FMERG参数具有更强的相关性。方法：这是一项回顾性观察性研究。回顾性分析65例RP患者的临床资料。FMERG由15度刺激点引起。评价了中央凹15度范围内SD-OCT图像中EZ和由EZ和视网膜色素上皮包围的外段（OS）区域的宽度。结果：FMERG振幅与EZ宽度（a波振幅r= 0.68，b波振幅r = 0.64）、OS面积（a波振幅r= 0.69，b波振幅r = 0.67）均呈显著正相关。然而，一些患者的EZ宽度较长，但FMERG严重减少。多元逐步回归分析显示，OS面积是唯一与FMERG振幅有显著相关性的独立预测因子（P< 0.001）。结论：OS面积是一种较好的预测黄斑生理功能的形态学结构。
Purpose: Our earlier study showed that the width of the intact ellipsoid zone (EZ) of the photoreceptors was significantly but weakly correlated with the amplitudes of the focal macular ERGs (FMERGs). The aim of this study was to determine a microstructure of the photoreceptors in the spectral-domain optical coherence tomographic (SD-OCT) images that was more strongly correlated with the FMERG parameters in eyes with retinitis pigmentosa (RP).Methods: This was a retrospective, observational study. The medical records of 65 patients with RP were reviewed. FMERGs were elicited by a 15-degree stimulus spot. The width of the EZ and the outer segment (OS) area surrounded by EZ and retinal pigment epithelium in the SD-OCT images within 15 degrees of the fovea were evaluated. Spearman correlation tests and multiple stepwise regression analyses were performed.Results: There was a strong correlation between the amplitudes of FMERGs and the EZ width (r= 0.68 for a-wave amplitude; r= 0.64 for b-wave amplitude), and also between the amplitudes of the FMERGs and the OS area (r= 0.69 for a-wave amplitude; r= 0.67 for b-wave amplitude). However, some patients had long EZ widths but had severely reduced FMERGs. Multiple stepwise regression analyses showed that the OS area was the only significant independent predictor of the amplitudes of FMERGs (P< 0.001).Conclusions: The OS area might be a better morphological structure to use to predict the physiological function of the macula.