Monte Carlo modeling of optoacoustic signals from human internal jugular veins.
Monte Carlo modeling of optoacoustic signals from human internal jugular veins.
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DOI：
10.1364/ao.46.004820
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发表时间：
2007-07
期刊：
影响因子：
1.9
通讯作者：
I. Patrikeev;Y. Petrov;I. Petrova;D. Prough;R. Esenaliev
中科院分区：
文献类型：
--
作者：
I. Patrikeev;Y. Petrov;I. Petrova;D. Prough;R. Esenaliev
监测血氧，特别是脑静脉氧合，对于管理各种危及生命的病症是必要的。光声技术可用于无创监测血管（包括大静脉）中的血氧。我们使用修改后的蒙特卡罗代码计算了来自模拟血管的圆柱体的光声信号，并分析了它们的时间分布。不同波长的入射近红外辐射下的积分光声信号的衰减率与正常氧合静脉血的有效衰减系数有关。我们在很宽的光谱范围内获得了该参数与血液有效衰减系数的良好相关性，这可能有助于提供准确而稳健的血液氧合光声监测。我们还估计了有效衰减系数计算的准确性。
Monitoring of blood oxygenation, in particular, cerebral venous oxygenation, is necessary for management of a variety of life-threatening conditions. An optoacoustic technique can be used for noninvasive monitoring of blood oxygenation in blood vessels, including large veins. We calculated optoacoustic signals from a cylinder mimicking a blood vessel using a modified Monte Carlo code and analyzed their temporal profiles. The rate of decrease of the integrated optoacoustic signal at different wavelengths of incident near-infrared radiation was related to the effective attenuation coefficient of normally oxygenated venous blood. We obtained good correlation of this parameter with the blood effective attenuation coefficient in a wide spectral range that may be useful in providing an accurate and robust optoacoustic monitoring of blood oxygenation. We also estimated the accuracy of effective attenuation coefficient calculations.