Catalytic Meerwein-Pondorf-Verley reduction by simple aluminum complexes
Catalytic Meerwein-Pondorf-Verley reduction by simple aluminum complexes
复制标题
DOI：
10.1021/ol0162116
复制
发表时间：
2001-07-26
期刊：
影响因子：
5.2
通讯作者：
Nguyen, ST
中科院分区：
文献类型：
--
作者：
Campbell, EJ;Zhou, HY;Nguyen, ST
使用简单的铝预催化剂成功地进行了催化MPV还原。使用（PrOH）-Pr-i作为还原剂，将烷基铝试剂转化为低聚集铝醇盐，其对于几种羰基底物的MPV还原具有高活性，产率（50-99%）。在（PrOH）-Pr-i还原2-甲基环己酮（cis/trans = 20/80）中实现了高度的顺/反选择性。当使用手性氢化物源还原2氯苯乙酮时，观察到高的对映选择性（68- 80%ee）。
[GRAPHICS]Catalytic MPV reduction was successfully carried out using simple aluminum precatalysts, Alkylaluminum reagents were converted to a low-aggregation aluminum alkoxide that was highly active for the MPV reduction of several carbonyl substrates in high yield (50-99%) using (PrOH)-Pr-i as the reducing agent. A high degree of cis/trans selectivity was achieved in the reduction of 2-methylcyclohexanone (cis/trans = 20/80) by (PrOH)-Pr-i. When chiral hydride sources were utilized in the reduction of 2 chloroacetophenone, high enantioselectivity (68-80% ee) was observed.