Effect of age and condition‐test interval (days) on an audio‐conditioned convulsive response in CF#1 mice
Effect of age and condition‐test interval (days) on an audio‐conditioned convulsive response in CF#1 mice
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年龄和条件测试间隔（天）对 CF1 小鼠音频条件惊厥反应的影响
DOI：
10.1002/dev.420010404
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发表时间：
1968
影响因子：
2.2
通讯作者：
G. B. Fink
中科院分区：
文献类型：
--
作者：
W. B. Iturrian;W. B. Iturrian;G. B. Fink
最初暴露在声音中会引起遗传性听觉敏感小鼠的癫痫发作。在股票（例如，CF#1）通常被认为是抗音频的，重复的声音暴露在某些条件下会诱发癫痫发作的易感性。易感性受年龄和最初与随后暴露于声音之间的间隔（天）的显著影响。先前的听觉刺激对于惊厥的发生是绝对必要的。年龄和条件测试间隔的选择产生了可预测的发病率和严重程度的癫痫发作。在任何时间间隔，12或45日龄小鼠的发病率约为5%。然而，18日龄的小鼠受到短暂的听觉刺激（60秒，95分贝），并在1，2，3，4，或5天的时间间隔进行测试，导致惊厥的发生率很高。阵挛性强直性惊厥的特点是在2或3天的时间间隔癫痫发作，但在5天，只有阵挛被视为。在没有进一步的声音刺激的情况下，小鼠显示出持续约5天的短暂的听觉敏感性。声音诱发的惊厥或重复的听觉刺激会延长敏感性。与其他声音诱发的惊厥相比，遗传控制的听源性危象的重要特征包括：基本的先前听觉刺激、短暂的易感性持续时间和对慢性噪声的适应。
The initial exposure to sound provokes seizures in genetically audio-sensitive mice. In a stock (e.g., CF#1) generally considered audio-resistant, repeated sound exposure will under certain conditions induce seizure susceptibility. Susceptibility is dramatically influenced by age and interval (days) between initial and subsequent exposure to sound. Previous auditory stimulation is absolutely essential for the genesis of convulsions. Selection of age and condition-test interval produced seizures of predictable incidence and severity. Incidence in 12- or 45-day-old mice was about 5% at any interval. However, 18-day-old mice subjected to brief auditory stimulation (60 sec at 95 db) and tested at intervals of 1, 2, 3, 4, or 5 days resulted in a high incidence of convulsions. Clonic-tonic convulsions characterized the seizures at the 2- or 3-day interval; but at 5 days only clonus was seen. Without further sound stimulation mice show a transitory audio-sensitivity lasting about 5 days. Sound-induced convulsions or repeated auditory stimulation prolong sensitivity. Important characteristics of the genetically controlled audiogenic crisis in contrast with other sound-induced convulsions include: the essential prior auditory stimulation, the brief duration of susceptibility, and the adaptation to chronic noise.