Cardiac and Peripheral Lymph Lipoproteins in Dogs Fed Cholesterol and Saturated Fat
Cardiac and Peripheral Lymph Lipoproteins in Dogs Fed Cholesterol and Saturated Fat
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饲喂胆固醇和饱和脂肪的狗的心脏和外周淋巴脂蛋白
DOI：
10.1161/01.atv.4.4.435
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
A. Angel
中科院分区：
文献类型：
--
作者：
P. Julien;B. Fong;A. Angel
正常犬饲粮中胆固醇含量为1%，饱和脂肪含量为30%，血浆、心淋巴和外周血淋巴中胆固醇浓度升高。心脏淋巴胆固醇的增加总是超过周围淋巴。高原期，血浆和外周淋巴中LDL胆固醇升高，心淋巴中无升高；胆固醇饲喂后，各室HDL2胆固醇升高，血浆HDLC出现（86.6±22.2 mg胆固醇/dl）。在心脏和外周淋巴中，分离出具有血浆高密度脂蛋白（HDL 1.063）的超离心和pevikon电泳特征的脂蛋白部分，其胆固醇含量分别为9.4±1.3和11.9±6.8 mg /dl。与外周淋巴相比，心脏淋巴中脂蛋白的淋巴/血浆（L/P）比率普遍较高。在胆固醇喂养的狗中，LDL的L/P比与对照狗相比降低，而HDL2未受影响，表明脂蛋白的选择性间质分布。琼脂糖电泳显示，淋巴脂蛋白的迁移速度比血浆脂蛋白快，表明其结构和/或组成发生了微妙的变化，这与脂蛋白在组织间隙发生修饰的观点一致。因此，正如淋巴所反映的那样，每个间质空间都具有脂蛋白的特征混合物，这些脂蛋白可以通过高胆固醇饮食以每种特定组织室特有的方式改变。
In normal dogs fed diets containing 1% cholesterol and 30% saturated fat, cholesterol concentration increased in plasma, cardiac lymph, and peripheral lymph. The increase in cardiac lymph cholesterol always exceeded that of peripheral lymph. At plateau, LDL cholesterol increased in plasma and peripheral lymph but not in cardiac lymph; HDL2 cholesterol increased in all compartments and HDLC appeared in plasma (86.6 ± 22.2 mg cholesterol/dl) with cholesterol feeding. In cardiac and peripheral lymph, a lipoprotein fraction with ultracentrifugal and pevikon electrophoretic characteristics of plasma HDLC (designated HDL 1.063) was isolated and contained 9.4 ± 1.3 and 11.9 ± 6.8 mg cholesterol/dl respectively. The lymph/plasma (L/P) ratios of lipoproteins were generally higher in cardiac lymph compared to peripheral lymph. In cholesterol-fed dogs, the L/P ratios of LDL were reduced compared to control dogs while HDL2 was unaffected, indicating selective interstitial distribution of lipoproteins. On agarose electrophoresis, lymph lipoproteins migrated faster than plasma lipoproteins, suggesting subtle changes in the structure and/or composition, findings consistent with the suggestion that lipoproteins undergo modification in the interstitial space. Thus, each interstitial space, as reflected by lymph, has a characteristic mixture of lipoproteins that can be altered by a high cholesterol diet in a manner that is unique to each particular tissue compartment.
DOI：
10.1073/pnas.78.10.6499
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
HENRIKSEN, T;MAHONEY, EM;STEINBERG, D
通讯作者：
STEINBERG, D
羊肺淋巴液中脂蛋白的分布。
DOI：
--
发表时间：
1983
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Cross,CE;Forte,TM;Gunther,RA;Kramer,GC
通讯作者：
Kramer,GC