5'-nor carbocyclic ribavirin.
5'-nor carbocyclic ribavirin.
复制标题
5-去甲碳环利巴韦林。
DOI：
10.1081/ncn-120026401
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Schneller,StewartW
中科院分区：
文献类型：
--
作者：
Tuncbilek,Meral;Schneller,StewartW
An efficient synthesis of 5′-nor carbocyclic ribavirin (4) is described in 13 steps from conveniently available (+)-(1R,4S)-4-hydroxy-2-cyclopenten-1-yl acetate (6). Compound4was evaluated against the following viruses: herpes simplex type 1 and 2, vaccinia, cowpox, smallpox, Ebola, hepatitis B, hepatitis C, adenovirus type 1, influenza A (H1N1 and H3N2), influenza B, parainfluenza type 3, Pichinde, Punta Toro A, respiratory syncytial, rhinovirus type 2, Venezuelan equine encephalitis, yellow fever, and West Nile. No activity was found nor was there any cytotoxicity to the viral host cells.
