FUNCTIONAL ADAPTATIONS OF RAT SKELETAL-MUSCLE ARTERIOLES TO AEROBIC EXERCISE TRAINING
FUNCTIONAL ADAPTATIONS OF RAT SKELETAL-MUSCLE ARTERIOLES TO AEROBIC EXERCISE TRAINING
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DOI：
10.1152/jappl.1992.72.6.2052
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发表时间：
1992-06-01
影响因子：
3.3
通讯作者：
BOHLEN, HG
中科院分区：
文献类型：
--
作者：
LASH, JM;BOHLEN, HG
这项研究验证了这样的假设，即小动脉的结构和功能适应都发生在大鼠的骨骼肌中，有氧训练8-10wk，跑步机运动。所使用的训练方案已被证明诱导了37%的足底柠檬酸合成酶活性增加，但没有导致本研究中使用的大鼠脊柱斜方肌或股薄肌中柠檬酸合成酶活性的提高。在静息状态下的大鼠脊髓斜方肌中，静息状态(SED)和训练状态(TR)大鼠的微动脉直径相似。然而，在1-8-HZ肌肉收缩中，大(1A)和中等(2A)大动脉扩张比例高于SED大鼠，尽管两组之间的被动力学特性(周长-被动壁张力关系)相似。大鼠脊髓斜方肌小动脉(3A)数有增加的趋势，1A型和2A型小动脉的被动直径增加约20%。相反，在股薄肌，微动脉直径和密度在SED和TR大鼠中是相同的，但毛细血管与肌肉纤维的比率在TR大鼠中大约高出15%。结果表明，有氧运动训练可以显著增加骨骼肌组织的功能性血管扩张，并诱导这些组织的血管密度略有增加，即使训练方案没有增加这些组织的氧化能力。
This study tested the hypothesis that both structural and functional adaptations of arterioles occur within the skeletal muscle of rats aerobically trained for 8-10 wk with treadmill exercise. The training regimen used has been shown to elicit a 37% increase in plantaris citrate synthase activity but did not result in an elevation in citrate synthase activity in the spinotrapezius or gracilis muscles of rats used in this study. In the in vivo resting spinotrapezius muscle, arteriole diameters were similar in sedentary (SED) and trained (TR) rats. However, large- (1A) and intermediate- (2A) sized arterioles dilated proportionately more in TR than in SED rats during 1- to 8-Hz muscle contractions, even though the passive mechanical properties (circumference-passive wall tension relationships) were similar between groups. Vascular casts demonstrated a trend for an increase in the number of small (3A) arterioles and an approximately 20% increase in the passive diameter of 1A and 2A arterioles in the spinotrapezius muscle of TR rats. In contrast, in the gracilis muscle, arteriole diameters and density were identical in SED and TR rats, but the capillary-to-muscle fiber ratio was approximately 15% higher in TR rats. The results suggest that aerobic exercise training can greatly increase functional vasodilation and induce a slight increase in vascular density in skeletal muscle tissues, even if the oxidative capacity of these tissues is not increased by the training regimen.