The biological role of the glycinergic synapse in early zebrafish motility
The biological role of the glycinergic synapse in early zebrafish motility
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DOI：
10.1016/j.neures.2011.06.003
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发表时间：
2011-09-01
影响因子：
2.9
通讯作者：
Ogino, Kazutoyo
中科院分区：
文献类型：
--
作者：
Hirata, Hiromi;Takahashi, Megumi;Ogino, Kazutoyo
甘氨酸介导脊髓、脑干和视网膜的快速抑制性神经传递。脊椎动物突触甘氨酸能传递的缺失会导致严重的运动缺陷，其特征是对突然的声音或触觉刺激产生夸大的惊吓反应，并伴有一过性肌肉僵硬。甘氨酸能突触的几个分子成分已被描述为哺乳动物突触发生的遗传学和生理学分析的结果。最近，人们用正向遗传学方法研究了斑马鱼的甘氨酸能突触。本文综述了斑马鱼甘氨酸能突触的分子组成，如甘氨酸受体亚单位、吉菲林、吉菲林结合蛋白和甘氨酸转运蛋白等，以及与斑马鱼甘氨酸能突触遗传分析相关的最新研究。(C)2011年爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
Glycine mediates fast inhibitory neurotransmission in the spinal cord, brainstem and retina. Loss of synaptic glycinergic transmission in vertebrates leads to a severe locomotion defect characterized by an exaggerated startle response accompanied by transient muscle rigidity in response to sudden acoustic or tactile stimuli. Several molecular components of the glycinergic synapse have been characterized as an outcome of genetic and physiological analyses of synaptogenesis in mammals. Recently, the glycinergic synapse has been studied using a forward genetic approach in zebrafish. This review aims to discuss molecular components of the glycinergic synapse, such as glycine receptor subunits, gephyrin, gephyrin-binding proteins and glycine transporters, as well as recent studies relevant to the genetic analysis of the glycinergic synapse in zebrafish. (C) 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.