Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4
Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4
复制标题
双特异性组蛋白去甲基化酶 KIAA1718 (KDM7A) 通过 FGF4 调节神经分化
DOI：
10.1038/cr.2010.5
复制
发表时间：
2010-02-01
期刊：
影响因子：
44.1
通讯作者：
Chen, Charlie Degui
中科院分区：
文献类型：
--
作者：
Huang, Chengyang;Xiang, Yang;Chen, Charlie Degui
Dimethylations of histone H3 lysine 9 and lysine 27 are important epigenetic marks associated with transcription repression. Here, we identified KIAA1718 (KDM7A) as a novel histone demethylase specific for these two repressing marks. Using mouse embryonic stem cells, we demonstrated that KIAA1718 expression increased at the early phase of neural differentiation. Knockdown of the gene blocked neural differentiation and the effect was rescued by the wild-type human gene, and not by a catalytically inactive mutant. In addition, overexpression of KIAA1718 accelerated neural differentiation. We provide the evidence that the pro-neural differentiation effect of KDM7A is mediated through direct transcriptional activation of FGF4, a signal molecule implicated in neural differentiation. Thus, our study identified a dual-specificity histone demethylase that regulates neural differentiation through FGF4.
