Modeling Human Natural Killer Cell Development in the Era of Innate Lymphoid Cells.
Modeling Human Natural Killer Cell Development in the Era of Innate Lymphoid Cells.
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DOI：
10.3389/fimmu.2017.00360
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发表时间：
2017
影响因子：
7.3
通讯作者：
Caligiuri MA
中科院分区：
文献类型：
--
作者：
Scoville SD;Freud AG;Caligiuri MA
自然杀伤（NK）细胞发现几十年后，它们在小鼠和人类中的发育途径尚未完全破译。越来越多的证据表明NK细胞可以在全身多个组织中发育。此外，在世纪之交后不久，提出了详细而全面的NK细胞发育模型。然而，随着最近对先天性淋巴样细胞（ILC）的其他亚型的鉴定和表征，其显示出与NK细胞发育中间体的一些重叠的功能和表型特征，人类NK细胞从早期造血祖细胞发育的不同阶段仍然不清楚。因此，有必要在新数据的背景下和ILC时代重新评估和改进NK细胞发育的旧模型。我们的研究小组致力于阐明人类NK细胞在次级淋巴组织（SLT）（包括扁桃体和淋巴结）中的发育途径。在这里，我们提供了一个更新的最新进展，已经取得了关于人类NK细胞的发展在SLTs，我们讨论这些新的发现的背景下，当代模型的ILC发展。
Decades after the discovery of natural killer (NK) cells, their developmental pathways in mice and humans have not yet been completely deciphered. Accumulating evidence indicates that NK cells can develop in multiple tissues throughout the body. Moreover, detailed and comprehensive models of NK cell development were proposed soon after the turn of the century. However, with the recent identification and characterization of other subtypes of innate lymphoid cells (ILCs), which show some overlapping functional and phenotypic features with NK cell developmental intermediates, the distinct stages through which human NK cells develop from early hematopoietic progenitor cells remain unclear. Thus, there is a need to reassess and refine older models of NK cell development in the context of new data and in the era of ILCs. Our group has focused on elucidating the developmental pathway of human NK cells in secondary lymphoid tissues (SLTs), including tonsils and lymph nodes. Here, we provide an update of recent progress that has been made with regard to human NK cell development in SLTs, and we discuss these new findings in the context of contemporary models of ILC development.