Versatile optical coherence tomography for imaging the human eye.
Versatile optical coherence tomography for imaging the human eye.
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DOI：
10.1364/boe.4.001031
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发表时间：
2013-07-01
影响因子：
3.4
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Tao A;Shao Y;Zhong J;Jiang H;Shen M;Wang J
我们证明了基于CMOS的谱域OCT（SD-OCT）用于角膜上皮、利姆布斯、眼表、接触透镜、晶状体透镜、视网膜和全眼活体成像的多功能眼科应用的可行性。该系统基于单个光谱仪和带有四个反射镜的交替参考臂。根据成像应用，使用检流计扫描仪在四个反射镜之间切换参考光束。空气中的轴向分辨率为7.7 μm，空气中的扫描深度高达37.7 mm，扫描速度高达每秒70，000条A线。该方法能够提供角膜上皮、接触透镜、眼表面和泪液弯月面的高分辨率成像。使用两个参考镜，零延迟线交替地放置在前角膜或后透镜上。通过配准和重叠两个图像对整个眼前段成像。当参考臂在四个参考镜之间切换时，测量通过瞳孔的全眼。在样品臂中安装60 D透镜后，使用该SD-OCT对视网膜成像，包括黄斑和视神经乳头。该系统展示了多用途眼科应用的多功能性和简单性。
We demonstrated the feasibility of a CMOS-based spectral domain OCT (SD-OCT) for versatile ophthalmic applications of imaging the corneal epithelium, limbus, ocular surface, contact lens, crystalline lens, retina, and full eye in vivo. The system was based on a single spectrometer and an alternating reference arm with four mirrors. A galvanometer scanner was used to switch the reference beam among the four mirrors, depending on the imaging application. An axial resolution of 7.7 μm in air, a scan depth of up to 37.7 mm in air, and a scan speed of up to 70,000 A-lines per second were achieved. The approach has the capability to provide high-resolution imaging of the corneal epithelium, contact lens, ocular surface, and tear meniscus. Using two reference mirrors, the zero delay lines were alternatively placed on the front cornea or on the back lens. The entire ocular anterior segment was imaged by registering and overlapping the two images. The full eye through the pupil was measured when the reference arm was switched among the four reference mirrors. After mounting a 60 D lens in the sample arm, this SD-OCT was used to image the retina, including the macula and optical nerve head. This system demonstrates versatility and simplicity for multi-purpose ophthalmic applications.