Fluvastatin therapy improves microcirculation in patients with hyperlipidaemia
Fluvastatin therapy improves microcirculation in patients with hyperlipidaemia
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DOI：
10.1016/s0021-9150(00)00567-0
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发表时间：
2001-04-01
期刊：
影响因子：
5.3
通讯作者：
Haak, T
中科院分区：
文献类型：
--
作者：
Haak, E;Abletshauser, C;Haak, T
本研究旨在探讨氟伐他汀对饮食控制不良的高脂血症(低密度脂蛋白胆固醇160 mg/dl、甘油三酯350 mg/dl)微循环的影响。经过4周的饮食磨合后，患者在双盲研究中随机接受氟伐他汀40毫克，每天两次(n=24)或安慰剂(n=24)，持续12周。用毛细血管显微镜和激光多谱勒血流仪观察治疗前、治疗后6周和12周对甲皱微循环的影响。毛细血管镜检显示氟伐他汀改善微循环，即血流峰值时间。闭塞后反应性充血从基线的19.77.2 S下降到第6周的12.3+/-9.5%S和10.66.5%的S(P<；0.0001)。用激光多谱勒流量计研究同一部位体温调节性毛细血管的微循环，证实了上述结果。在氟伐他汀治疗期间，总胆固醇和低密度脂蛋白胆固醇显著降低。总之，氟伐他汀治疗可在6周内改善高胆固醇血症患者营养性和体温调节性毛细血管的微循环。2001爱思唯尔科学爱尔兰有限公司。版权所有。
The purpose of this study was to investigate the effect of fluvastatin on the microcirculation of patients with hyperlipidaemia (low-density lipoprotein cholesterol > 160 mg/dL, triglycerides < 350 mg/dl) inadequately controlled by diet. After a dietary run-in of 4 weeks, patients were randomised in a double-blind study to receive fluvastatin 40 mg twice daily (n = 24) or placebo (n = 24) for 12 weeks. The effect on microcirculation was assessed using capillary microscopy and laser Doppler fluxmetry at the nailfold at baseline and at 6 and 12 weeks after initiation of therapy. Capillaroscopy showed that fluvastatin improved microcirculation, i.e. time to peak flow. during postocclusive reactive hyperaemia dropped from 19.7 7.2 s at baseline to 12.3 +/- 9.5 s at week 6 (P < 0.01) and 10.6 6.5 s at week 12 (P < 0.0001). These results were confirmed using laser Doppler fluxmetry to study microcirculation in thermoregulatory capillaries at the same site. A significant decrease in total and LDL-cholesterol was achieved during fluvastatin therapy. In conclusion, fluvastatin therapy improves microcirculation in nutritive as well as thermoregulatory capillaries in hypercholesterulaemic patients within 6 weeks. 2001 Elsevier Science Ireland Ltd. All rights reserved.