Causative Factors in Cerebral Palsy
Causative Factors in Cerebral Palsy
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DOI：
10.1097/grf.0b013e318187087c
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发表时间：
2008-12-01
影响因子：
1.5
通讯作者：
Nelson, Karin B.
中科院分区：
文献类型：
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作者：
Nelson, Karin B.
脑性瘫痪（CP）的病因因胎龄和临床类型不同而不同。胎盘脱垂、脐带脱垂和子宫破裂等分娩灾难会显著增加CP的风险。幸运的是，这些情况并不常见，有时甚至无法生存;单独和集体地，它们只占CP的一小部分。与CP风险增加相关的其他因素包括早产、宫内感染或分娩时母亲发热、缺血性卒中、先天性畸形、非典型宫内生长（胎龄受限或过度）和多胎妊娠并发症。虽然任何一个因素，如果严重的话，可能足以导致CP，但更常见的是多个危险因素的存在，破坏防御机制并导致CP。与环境压力相互作用的遗传脆弱性的贡献是我们对CP致病因素的理解的一个新兴方面。
Causative factors in cerebral palsy (CP) vary to some degree according to gestational age group and clinical CP subtype. Such catastrophes of birth as placental abruption, cord prolapse, and uterine rupture sharply heighten risk of CP. These conditions are fortunately uncommon, and are sometimes not survived; individually and collectively they account for only a small proportion of CP. Among other factors associated with increased risk of CP are prematurity, intrauterine exposure to infection or maternal fever in labor, ischemic stroke, congenital malformations, atypical intrauterine growth (restricted or excessive for gestational age), and complications of multiple gestations. Although any 1 factor, if severe, may be sufficient to cause CP, more often it is the presence of multiple risk factors that overwhelms defense mechanisms and leads to CP. The contribution of genetic vulnerabilities that interact with environmental stressors is an emerging aspect of our understanding of causative factors in CP.