Antigenic relatedness between glycoproteins of human respiratory syncytial virus subgroups A and B: evaluation of the contributions of F and G glycoproteins to immunity
Antigenic relatedness between glycoproteins of human respiratory syncytial virus subgroups A and B: evaluation of the contributions of F and G glycoproteins to immunity
复制标题
人呼吸道合胞病毒A和B亚型糖蛋白之间的抗原相关性：评估F和G糖蛋白对免疫的贡献
作者：
P. Johnson;R. Olmsted;G. Prince;B. Murphy;D. Alling;E. Walsh;P. Collins
人呼吸道合胞病毒 (RSV) A 亚型和 B 亚型之间的抗原相关性程度是根据 RSV 呼吸道感染在棉鼠中诱导的抗体反应来估计的。 RSV 感染诱导的抗体反应的糖蛋白特异性酶联免疫吸附测定表明，A 亚型和 B 亚型的 F 糖蛋白在抗原上密切相关（相关性，R 约为 50%），而 G 糖蛋白仅存在较远的相关性（R 约为 5%）。在感染两个亚组 RSV 的棉鼠的中和抗体中观察到中等水平的抗原相关性（R 约 25%）。由痘苗-A2-F诱导的针对A亚组F糖蛋白的免疫赋予了高水平的保护，其与针对任一亚组的RSV攻击的程度相当。相比之下，痘苗-A2-G 诱导的针对 A 亚组 G 糖蛋白的免疫提供了不太完整但显着的保护。重要的是，在痘苗-A2-G免疫动物中，同源攻击病毒复制的抑制明显大于异源病毒观察到的抑制（13倍）。
The degree of antigenic relatedness between human respiratory syncytial virus (RSV) subgroups A and B was estimated from antibody responses induced in cotton rats by respiratory tract infection with RSV. Glycoprotein-specific enzyme-linked immunosorbent assays of antibody responses induced by RSV infection demonstrated that the F glycoproteins of subgroups A and B were antigenically closely related (relatedness, R approximately 50%), whereas the G glycoproteins were only distantly related (R approximately 5%). Intermediate levels of antigenic relatedness (R approximately 25%) were seen in neutralizing antibodies from cotton rats infected with RSV of the two subgroups. Immunity against the F glycoprotein of subgroup A, induced by vaccinia-A2-F, conferred a high level of protection which was of comparable magnitude against challenge by RSV of either subgroup. In comparison, immunity against the G glycoprotein of subgroup A, induced by vaccinia-A2-G, conferred less complete, but significant, protection. Importantly, in vaccinia-A2-G-immunized animals, suppression of homologous challenge virus replication was significantly greater (13-fold) than that observed for the heterologous virus.
影响因子：
3.7
作者：
Salehi, Sattar;Ghazizadeh, Mohammadreza Jalili;Tabesh, Massoud
通讯作者：
Tabesh, Massoud