Changes in heart period, heart period variability, and a spectral analysis estimate of respiratory sinus arrhythmias during aortic nerve stimulation in rabbits.
Changes in heart period, heart period variability, and a spectral analysis estimate of respiratory sinus arrhythmias during aortic nerve stimulation in rabbits.
复制标题
兔主动脉神经刺激期间心脏周期的变化、心脏周期变异性以及呼吸性窦性心律失常的频谱分析估计。
DOI：
10.1111/j.1469-8986.1984.tb00197.x
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发表时间：
1984
期刊：
影响因子：
3.7
通讯作者：
Ackles,PK
中科院分区：
文献类型：
--
作者：
McCabe,PM;Yongue,BG;Porges,SW;Ackles,PK
在乌拉坦麻醉的兔主动脉降压神经(ADN)刺激对心脏产生负性变时性作用的过程中，观察心脏周期、心脏周期变异性(HPV)和呼吸成分的变化。用频谱分析法定量分析HPV的呼吸成分，即呼吸性窦性心律失常(RSA)。从频谱分析中得出的统计量描述了RSA，V̂，被认为对迷走神经对心脏的影响很敏感。刺激ADN可显著增加V-̂、心率和HPV值。然而，与V̂和心动周期不同的是，HPV值在刺激结束后仍然升高。心得安给药不改变V-̂、心率或人乳头瘤病毒诱发增加的幅度。相比之下，阿托品的使用消除了所有三项措施中由于刺激而导致的增加。心动周期与刺激电流强度呈单调关系。在心得安给药后，这种关系消失了，建议进行同情调解。结果表明，V̂对迷走神经对心脏的影响是敏感的。此外，V̂的反应方式通常与心动周期和HPV不同。
Changes in heart period, heart period variance (HPV), and the respiratory component of HPV were examined during enhanced negative chronotropic influences on the heart produced by aortic depressor nerve (ADN) stimulation in urethane anesthetized rabbits. Spectral analysis was used to quantify the respiratory component of HPV, respiratory sinus arrhythmia (RSA). The statistic derived from spectral analysis which describes RSA, V̂, has been proposed to be sensitive to vagal influences on the heart. Stimulation of the ADN significantly increased V̂, heart period, and HPV. However, unlike V̂ and heart period, HPV values remained elevated following the end of stimulation. Propranolol administration did not alter the magnitude of the evoked increase in V̂, heart period, or HPV. In contrast, administration of atropine abolished the increases due to stimulation in all three measures. Heart period exhibited a monotonic relationship with stimulation current intensity. This relationship disappeared after propranolol administration suggesting sympathetic mediation. The results suggest that V̂ is sensitive to manipulations of vagal influences on the heart. In addition, V̂ often responds in a different manner from heart period and HPV.