Interactions between antihyperglycemic drugs and the reninangiotensin system: Putative roles in COVID-19. A mini-review
Interactions between antihyperglycemic drugs and the reninangiotensin system: Putative roles in COVID-19. A mini-review
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DOI：
10.1016/j.dsx.2020.04.040
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发表时间：
2020-07-01
影响因子：
10
通讯作者：
Shehadeh, Naim
中科院分区：
文献类型：
--
作者：
Nakhleh, Afif;Shehadeh, Naim
背景：糖尿病与 2019 年冠状病毒病 (COVID-19) 更严重的病程有关。严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 利用血管紧张素转换酶 II (ACE2) 受体进入宿主细胞。我们的目的是评估降血糖药物与肾素血管紧张素系统 (RAS) 之间的相互作用及其在 COVID-19 中的假定作用。方法：使用 Pubmed 进行文献检索，回顾高血糖、RAS 和 COVID-19 之间的相互关系以及降血糖药物的作用。结果：RAS 在葡萄糖稳态中发挥重要作用，并可能在 COVID-19 诱导的肺损伤中发挥作用。一些抗高血糖药物可调节 RAS，并可能减轻血管紧张素 II 对肺损伤的有害影响。此外，大多数降糖药物在肺损伤动物模型中表现出抗炎作用。结论：一些降糖药物可能对 COVID-19 引起的肺损伤具有保护作用。早期胰岛素治疗似乎在减轻肺损伤方面非常有希望。 (C) 2020 年印度糖尿病。由爱思唯尔有限公司出版。保留所有权利。
Background: Diabetes mellitus is associated with a more severe course of coronavirus disease 2019 (COVID-19). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensinconverting enzyme II (ACE2) receptor for host cell entry. We aimed to assess the interactions between antihyperglycemic drugs and the renin-angiotensin system (RAS) and their putative roles in COVID-19.Methods: A literature search was performed using Pubmed to review the interrelationships between hyperglycemia, RAS and COVID-19, and the effects of antihyperglycemic medications.Results: The RAS has an essential role in glucose homeostasis and may have a role in COVID-19-induced lung injury. Some antihyperglycemic medications modulate RAS and might hypothetically alleviate the deleterious effect of angiotensin II on lung injury. Furthermore, most antihyperglycemic medications showed anti-inflammatory effects in animal models of lung injury.Conclusions: Some antihyperglycemic medications might have protective effects against COVID-19induced lung injury. Early insulin therapy seems very promising in alleviating lung injury. (C) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.