Age-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice.
Age-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice.
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DOI：
10.1097/ana.0b013e3181d56c98
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发表时间：
2010-07
影响因子：
3.7
通讯作者：
Giffard RG
中科院分区：
文献类型：
--
作者：
Barreto G;Huang TT;Giffard RG
Impaired locomotor activity and spatial memory are common features in the natural aging process, and aging is an important risk factor for neurodegenerative disease and postoperative cognitive dysfunction. To characterize age-related changes in psychomotor performance we assessed sensorimotor activity, spatial learning and memory in C57BL/6 mice using the Rotarod, foot fault and Barnes maze tests. Old mice exhibit significant deficits in locomotor activity and spatial memory relative to young mice, but improve with training. These tests will be useful to assess outcome in neurodegenerative disease and postoperative cognitive dysfunction models performed in aged mice.
