Cholangiocarcinoma.
Cholangiocarcinoma.
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DOI：
10.1016/j.path.2018.02.005
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发表时间：
2018-06-01
影响因子：
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通讯作者：
Krasinskas, Alyssa M
中科院分区：
文献类型：
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作者：
Krasinskas, Alyssa M
本文主要讨论肝内和肝外胆管细胞癌。概述了基于解剖位置、宏观生长模式、微观特征和起源细胞的各种分类方案。本文讨论了肝内胆管细胞癌和肝外胆管细胞癌的临床病理、免疫组织化学和分子生物学差异，以及肝内胆管细胞癌两亚型的差异。最后，对前驱病变、预后、治疗和潜在的新的靶向治疗进行了综述。
This article focuses on cholangiocarcinoma, both intrahepatic and extrahepatic. The various classification schemes based on anatomic location, macroscopic growth pattern, microscopic features, and cell of origin are outlined. The clinicopathologic, immunohistochemical and molecular differences between intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, as well as differences in the 2 subtypes of intrahepatic cholangiocarcinoma, are discussed. Finally, precursor lesions, prognosis, treatment, and promising new potential targeted therapies are reviewed.