Adolescent rats show cognitive rigidity in a test of attentional set shifting.
Adolescent rats show cognitive rigidity in a test of attentional set shifting.
复制标题
DOI：
10.1002/dev.20537
复制
发表时间：
2011-05
影响因子：
2.2
通讯作者：
L. A. Newman;J. McGaughy
中科院分区：
文献类型：
--
作者：
L. A. Newman;J. McGaughy
由于精神分裂症、注意力缺陷障碍和情绪障碍等神经精神疾病都会影响执行功能，并且很可能在成年之前被诊断出来，因此了解执行功能的正常个体发育非常重要。先前的行为研究表明，青少年的执行功能与成年人不同。在本研究中，我们使用先前经过验证的认知测试，即维度内/维度外 (ID/ED) 设定转移任务，来评估青少年和成年雄性 Long-Evans 大鼠的注意力设定转移和逆转学习。这些数据表明，青春期大鼠的认知能力比成年大鼠更加僵化，并且在注意力集中的转移方面有障碍，但在注意力的形成方面没有障碍。当引入不相关的刺激维度作为复杂刺激的一部分时，青春期大鼠也比成年大鼠更容易分心。此外，我们发现，与逆转学习相比，注意力转移在更早的年龄就变得像成人一样。由于这些功能是由不同的前额皮质亚区（即前边缘皮质和眶额皮质）介导的，因此我们假设前额皮质亚区表现出略有不同的发育轨迹。
As neuropsychiatric disorders such as schizophrenia, attention deficit disorder, and mood disorders all impact executive function and are likely to be diagnosed prior to adulthood, it is important to understand the normal ontogeny of executive function. Previous behavioral research has shown that adolescents' executive function is different than that of adults. In the present study, we use a previously validated cognitive test, the intradimensional/extradimensional (ID/ED) set-shifting task, to assess attentional set shifting and reversal learning in adolescent and adult, male, Long-Evans rats. These data suggest that adolescent rats are more cognitively rigid than adult rats and have impairments in the shifting, but not formation, of an attentional set. Adolescent rats are also more susceptible to distraction than adult rats when an irrelevant stimulus dimension is introduced as part of a complex stimulus. Moreover, we find that attentional set shifting becomes adult-like at an earlier age than reversal learning. As these functions are mediated by distinct prefrontal subregions, that is, the prelimbic and orbitofrontal cortices, respectively, we hypothesize that prefrontal cortical subregions show slightly different developmental trajectories.