Cancer, cognitive impairment, and meditation
Cancer, cognitive impairment, and meditation
复制标题
DOI：
10.1080/02841860802415535
复制
发表时间：
2009-01-01
期刊：
影响因子：
3.1
通讯作者：
Cohen, Lorenzo
中科院分区：
文献类型：
--
作者：
Biegler, Kelly A.;Chaoul, M. Alejandro;Cohen, Lorenzo
背景和目标。癌症相关的认知障碍已被公认为是癌症患者和幸存者生活质量的重要限制因素。除了行为测量的缺陷外，还报告了神经结构和功能的异常。在本文中，我们回顾了认知障碍和癌症，潜在的干预措施，冥想和认知功能，冥想和癌症的文献研究结果。此外，我们还提出了关于冥想练习如何有助于减轻客观和主观认知功能的假设，以及将冥想计划纳入癌症患者和幸存者治疗癌症相关认知缺陷的优势。调查结果。已经假设各种因素在癌症相关的认知障碍中起作用，包括化疗、激素水平降低、促炎性免疫反应、疲劳和痛苦。药物治疗如哌甲酯或莫达非尼已被建议减轻认知缺陷。虽然最初的报告表明它们是有效的，但一些药物治疗有副作用，可能无法缓解与多模式癌症治疗相关的其他症状，包括睡眠障碍，恶心和疼痛。最近的几项研究调查了冥想计划的影响，报告了行为和相应的神经生理学调节，这可能对减轻癌症相关的认知障碍特别有效。这些项目也被证明可以减轻压力，疲劳，恶心和疼痛，改善情绪和睡眠质量。结论.随着癌症治疗的日益成功以及恢复以前的家庭，社会和工作活动的能力，症状管理和生活质量是生存的重要组成部分。我们认为，冥想可能有助于改善癌症相关的认知功能障碍，减轻其他癌症相关的后遗症，并应充分研究作为癌症治疗的辅助手段。
Background and objectives. Cancer-related cognitive impairment has been acknowledged as a substantial limiting factor in quality of life among cancer patients and survivors. In addition to deficits on behavioral measures, abnormalities in neurologic structure and function have been reported. In this paper, we review findings from the literature on cognitive impairment and cancer, potential interventions, meditation and cognitive function, and meditation and cancer. In addition, we offer our hypotheses on how meditation practice may help to alleviate objective and subjective cognitive function, as well as the advantages of incorporating a meditation program into the treatment of cancer patients and survivors for cancer-related cognitive deficits. Findings. Various factors have been hypothesized to play a role in cancer-related cognitive impairment including chemotherapy, reduced hormone levels, proinflammatory immune response, fatigue, and distress. Pharmacotherapies such as methylphenidate or modafinil have been suggested to alleviate cognitive deficits. While initial reports suggest they are effective, some pharmacotherapies have side effects and may not relieve other symptoms associated with multimodal cancer treatment including sleep disturbance, nausea and pain. Several recent studies investigating the effects of meditation programs have reported behavioral and corresponding neurophysiological modulations that may be particularly effective in alleviating cancer-related cognitive impairment. Such programs also have been shown to reduce stress, fatigue, nausea and pain, and improve mood and sleep quality. Conclusions. With the increasing success of cancer treatment and the ability to return to previous family, social, and work activities, symptom management and quality of life are an essential part of survivorship. We propose that meditation may help to improve cancer related cognitive dysfunction, alleviate other cancer-related sequelae, and should be fully investigated as an adjuvant to cancer treatment.