Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease.
Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease.
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DOI：
10.1186/s13075-015-0645-y
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发表时间：
2015-05-15
影响因子：
4.9
通讯作者：
Sacre S
中科院分区：
文献类型：
--
作者：
Mullen LM;Chamberlain G;Sacre S
先天免疫系统的模式识别受体是抵抗病原体的第一道防线的一部分。然而，它们也有能力对组织损伤和炎症部位经常升高的危险信号做出反应。模式识别受体的意外激活已被认为是许多疾病（包括炎性风湿性疾病）的发病机制。长期炎症最常导致疼痛和组织损伤。特别是，Toll样受体和形成炎性小体的核苷酸结合寡聚化结构域样受体已被假定为类风湿性关节炎、骨关节炎、痛风和系统性红斑狼疮中观察到的炎症的关键贡献者。因此，在临床中靶向这些受体用于治疗性治疗的兴趣越来越大。在这里，模式识别受体在这些疾病的发病机制中的作用进行了讨论，与干预措施的发展，以调节这些潜在的治疗靶点的活性的更新。
The pattern recognition receptors of the innate immune system are part of the first line of defence against pathogens. However, they also have the ability to respond to danger signals that are frequently elevated during tissue damage and at sites of inflammation. Inadvertent activation of pattern recognition receptors has been proposed to contribute to the pathogenesis of many conditions including inflammatory rheumatic diseases. Prolonged inflammation most often results in pain and damage to tissues. In particular, the Toll-like receptors and nucleotide-binding oligomerisation domain-like receptors that form inflammasomes have been postulated as key contributors to the inflammation observed in rheumatoid arthritis, osteoarthritis, gout and systemic lupus erythematosus. As such, there is increasing interest in targeting these receptors for therapeutic treatment in the clinic. Here the role of pattern recognition receptors in the pathogenesis of these diseases is discussed, with an update on the development of interventions to modulate the activity of these potential therapeutic targets.
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DOI：
10.1038/nri2569
发表时间：
2009-07
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Geijtenbeek TB;Gringhuis SI
通讯作者：
Gringhuis SI
影响因子：
--
作者：
Bobacz, K.;Sunk, I. G.;Smolen, J. S.
通讯作者：
Smolen, J. S.
影响因子：
30.5
作者：
Baroja-Mazo, Alberto;Martin-Sanchez, Fatima;Pelegrin, Pablo
通讯作者：
Pelegrin, Pablo
影响因子：
4.9
作者：
Gagne, Valerie;Marois, Louis;Fernandes, Maria J. G.
通讯作者：
Fernandes, Maria J. G.
影响因子：
15.9
作者：
Abdollahi-Roodsaz, Shahla;Joosten, Leo A. B.;Van den Berg, Wim B.
通讯作者：
Van den Berg, Wim B.