Transfer of the UAP56 Interaction Motif of Human Cytomegalovirus pUL69 to Its Murine Cytomegalovirus Homolog Converts the Protein into a Functional mRNA Export Factor That Can Substitute for pUL69 during Viral Infection
Transfer of the UAP56 Interaction Motif of Human Cytomegalovirus pUL69 to Its Murine Cytomegalovirus Homolog Converts the Protein into a Functional mRNA Export Factor That Can Substitute for pUL69 during Viral Infection
复制标题
将人巨细胞病毒 pUL69 的 UAP56 相互作用基序转移到其鼠巨细胞病毒同源物中，将蛋白质转化为功能性 mRNA 输出因子，可在病毒感染期间替代 pUL69
作者：
Barbara Zielke;Nadine Wagenknecht;Caroline Pfeifer;Katrin Zielke;Marco Thomas;T. Stamminger
ABSTRACT Nucleocytoplasmic shuttling and interaction with the cellular mRNA export factor UAP56 are prerequisites for the mRNA export activity of human cytomegalovirus (HCMV) pUL69. Although the murine cytomegalovirus homolog pM69 shuttles, it fails to export mRNAs due to its inability to recruit UAP56. However, chimeric proteins comprising pM69 fused to N-terminal pUL69 fragments, including its UAP56 interaction motif, acquire mRNA export activity. Importantly, growth curves of recombinant HCMVs illustrate that such a chimeric protein, but not pM69, substitutes for pUL69 during HCMV infection.
影响因子：
2.7
作者：
Tischer, BK;von Einem, J;Osterrieder, N
通讯作者：
Osterrieder, N