Pentagon drawing and neuropsychological performance in Dementia with Lewy Bodies, Alzheimer's disease, Parkinson's disease and Parkinson's disease with dementia
Pentagon drawing and neuropsychological performance in Dementia with Lewy Bodies, Alzheimer's disease, Parkinson's disease and Parkinson's disease with dementia
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DOI：
10.1002/gps.1094
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发表时间：
2004-04-01
影响因子：
4
通讯作者：
Tovée, MJ
中科院分区：
文献类型：
--
作者：
Cormack, F;Aarsland, D;Tovée, MJ
目的 鉴于路易体痴呆 (DLB) 患者存在严重的抗精神病药敏感性以及对胆碱酯酶抑制剂的优先反应的报道，早期准确诊断路易体痴呆 (DLB) 以便采取适当的临床治疗是当务之急。有人认为，结构性失用症在 DLB 中普遍存在，并且可能提供该疾病的敏感标志。 方法 本研究检查了 100 名 DLB 患者、50 名阿尔茨海默病 (AD) 患者、81 名帕金森病 (PD) 患者的五边形图，其中 36 名患有痴呆 (PDD)。这项任务的表现与 MMSE 和 CAMCOG 量表的认知表现相关。 结果发现，DLB 患者画出的五边形明显比 AD 或 PD 患者差，但 PDD 患者则不然。 AD 和 PDD 组的绘图分数与 MMSE 分数显着相关，但 DLB 组则不然。对 AD 和 DLB 患者的结构表现的神经心理学相关性进行更详细的分析，结果表明，AD 患者的损伤表现出广泛的认知基础，而 DLB 绘图仅与感知和实践相关。 结论 这项研究表明，DLB 受试者表现出五边形复制损伤，与更多的整体认知损伤无关，而 PD 患者则相对未受损伤 对五边形复制以及 AD 和 PDD 患者的研究表明，他们的复制障碍与更多的整体认知缺陷存在联系。版权所有 (C) 2004 John Wiley Sons, Ltd.
Objectives Early and accurate diagnosis of Dementia with Lewy Bodies (DLB) to allow the appropriate clinical treatment is a priority, given reports of severe neuroleptic sensitivity and a preferential response to cholinesterase inhibitors in these patients. There have been suggestions that constructional apraxia is prevalent in DLB, and may provide a sensitive marker of the disease.Methods This study examined the pentagon drawings of 100 DLB patients, 50 Alzheimer's disease (AD) patients, 81 Parkinson's disease (PD) patients of whom 36 suffered from dementia (PDD). Performance on this task was correlated with cognitive performance on the MMSE and CAMCOG scales.Results Patients with DLB were found to draw significantly worse pentagons than those with AD or PD, but not those with PDD. Drawing scores were significantly correlated with MMSE scores for the AD and PDD groups but not those with DLB. More detailed analysis of the neuropsychological correlates of constructional performance for patients with AD and DLB, revealed that those with AD showed a broad cognitive basis to their impairment, in DLB drawing was linked only to perception and praxis.Conclusions This study has suggests that DLB subjects show an impairment of pentagon copying that is dissociable from more global cognitive impairments, whereas PD patients are relatively unimpaired on pentagon copying and AD and PDD patients show a linkage of their impairment in copying with more global cognitive deficits. Copyright (C) 2004 John Wiley Sons, Ltd.