Beyond standard adjuvant therapy for colon cancer: role of nonstandard interventions.
Beyond standard adjuvant therapy for colon cancer: role of nonstandard interventions.
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DOI：
10.1053/j.seminoncol.2011.05.007
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发表时间：
2011-08
影响因子：
4
通讯作者：
Meyerhardt JA
中科院分区：
文献类型：
--
作者：
Meyerhardt JA
流行病学和科学研究表明，饮食和其他生活方式因素对患结直肠癌的风险有重大影响。肥胖，红肉消费，西式饮食，酒精和吸烟会影响患结直肠癌的风险，而体育活动，维生素D，绝经后雌激素使用，阿司匹林和NSAID会降低风险。直到最近，这些可改变的因素中是否有任何一个会影响已经诊断为结直肠癌的患者的预后，在很大程度上还是未知的。然而，数据正在出现的因素，可能会影响疾病复发率和死亡率的结直肠癌幸存者。前瞻性观察性研究表明，诊断后增加运动和避免西式饮食与标准治疗后早期结直肠癌复发风险降低和总生存率提高相关。II级和III级肥胖（BMI ≥ 35 kg/m2）患者的复发风险适度增加。定期使用阿司匹林或环氧合酶-2抑制剂可降低复发率，并增加血清维生素D水平。相比之下，诊断后体重的变化或吸烟状态（从未，过去或现在）与诊断后的结果无关。将审查支持这些观察结果的数据，讨论潜在的作用机制，并提出今后的步骤。
Epidemiologic and scientific research indicates that diet and other lifestyle factors have a significant influence on the risk of developing colorectal cancer. Obesity, consumption of red meat, a Western pattern diet, alcohol, and smoking influence one’s risk of developing colorectal cancer while physical activity, vitamin D, post-menopausal estrogen use, aspirin and NSAIDs decrease one’s risk. Until recently, it was largely unknown if any of these modifiable factors influence the outcomes of patients already diagnosed with colorectal cancer. However, data are emerging of factors that may influence disease recurrences and mortality for colorectal cancer survivors. Prospective observational studies have shown that increased exercise after diagnosis and avoidance of a Western pattern diet are associated with reduced risk of cancer recurrence and improved overall survival in early- stage colorectal cancer after standard therapy. Patients with class II and III obesity (BMI ≥ 35 kg/m2) have a modestly increased risk of recurrence. Regular use of aspirin or cyclooxygenase-2 inhibitors decrease recurrence rates as well as increased serum vitamin D levels. In contrast, change of weight after diagnosis or smoking status (never, past or current) are not associated with outcomes after diagnosis. The data supporting these observations will be reviewed, potential mechanisms of actions will be discussed and next steps forward will be proposed.
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影响因子：
158.5
作者：
Bertagnolli, Monica M.;Eagle, Craig J.;Hawk, Ernest T.
通讯作者：
Hawk, Ernest T.
DOI：
10.1089/acm.1997.3.215
发表时间：
1997-01-01
期刊：
Journal of alternative and complementary medicine (New York, N.Y.)
影响因子：
--
作者：
Courneya, K S;Friedenreich, C M
通讯作者：
Friedenreich, C M
影响因子：
24.5
作者：
Dray, X;Boutron-Ruault, MC;Faivre, J
通讯作者：
Faivre, J
影响因子：
1.9
作者：
BJORK, J;NILSSON, J;JOHANSSON, C
通讯作者：
JOHANSSON, C
影响因子：
45.3
作者：
Blanchard, Christopher M.;Courneya, Kerry S.;Stein, Kevin
通讯作者：
Stein, Kevin