Glycans and glycan-specific IgE in clinical and molecular allergology: Sensitization, diagnostics, and clinical symptoms
Glycans and glycan-specific IgE in clinical and molecular allergology: Sensitization, diagnostics, and clinical symptoms
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DOI：
10.1016/j.jaci.2017.04.019
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发表时间：
2017-08-01
影响因子：
14.2
通讯作者：
Jappe, Uta
中科院分区：
文献类型：
--
作者：
Homann, Arne;Schramm, Gabriele;Jappe, Uta
聚糖特异性IgE抗体在多种不同的天然过敏原上与高度相似甚至相同的碳水化合物结构发生交叉反应，即所谓的交叉反应性碳水化合物决定因子（CCDs）。在临床实践中，ccd经常干扰体外过敏诊断的特异性，从而影响个体患者的过敏治疗决策。引人注目的是，这些针对ccd的IgE抗体通常不会引起临床相关的过敏症状。另一方面，与ige结合的聚糖过敏原半乳糖- α -(1,3)-半乳糖（α -gal）与肉类过敏中ige介导的延迟性过敏反应有关。造成这种差异的原因尚不清楚。gal的发现激发了关于抗聚糖IgE与过敏性疾病相关性的新讨论和研究。本文就糖聚糖和糖特异性IgE在过敏原致敏和过敏诊断中的作用作一综述。由于寄生虫感染引起的免疫环境与过敏性疾病相似，因此本文讨论了针对寄生虫糖蛋白的聚糖特异性抗体与过敏原上的聚糖结构的关联
Glycan-specific IgE antibodies cross-react with highly similar or even identical carbohydrate structures on a variety of different natural allergens, the so-called cross-reactive carbohydrate determinants (CCDs). In clinical practice CCDs often interfere with the specificity of in vitro allergy diagnostics, thus impairing allergy therapy decisions for individual patients. Strikingly, these IgE antibodies directed against CCDs often do not cause clinically relevant allergy symptoms. On the other hand, the IgE-binding glycan allergen galactose-alpha-(1,3)-galactose (alpha-Gal) is associated with IgE-mediated delayed anaphylaxis in meat allergy. The reason for this discrepancy is not known. The discovery of -Gal stimulated new discussions and investigations regarding the relevance of anti-glycan IgE for allergic diseases. In this review the effect of glycans and glycanspecific IgE on sensitization to allergens and allergy diagnosis is described. Because parasite infections elicit a similar immunologic environment as allergic diseases, the association of glycan-specific antibodies against parasite glycoproteins with glycan structures on allergens is discussed