Microbial persistence. II. Characteristics of the sterile state of tubercle bacilli.
Microbial persistence. II. Characteristics of the sterile state of tubercle bacilli.
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DOI：
10.1084/jem.123.3.469
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发表时间：
1966-03-01
期刊：
影响因子：
--
通讯作者：
McDermott W
中科院分区：
文献类型：
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作者：
McCune RM;Feldmann FM;McDermott W
当暴露于吡嗪酰胺和异烟肼时，结核杆菌在组织中呈现长期持续无菌状态的能力是一种高度特异性的药物-微生物现象，其中宿主参与并不重要。虽然吡嗪酰胺具有杀菌作用，但异烟肼的作用是特定的和必要的。异烟肼用于将单独使用吡嗪酰胺时不规则发生的现象转化为以高度均匀性发生的现象。这些观察结果表明，异烟肼和吡嗪酰胺（或其母体烟酰胺）之间存在竞争，竞争结核杆菌内或结核杆菌上的位点或入口，并进行灭菌，异烟肼显然必须首先到达该位点。罕见的完全绝育失败似乎取决于吡嗪酰胺耐药性的出现，这种耐药性阻止了两种药物的必要依赖作用。然而，已经处于不育状态的人口仍然受到持续的药物影响。这是对无菌杆菌的直接作用，还是使环境不利于微生物复苏而产生的间接影响，从目前的观察中还不能确定。
The capability of tubercle bacilli to assume a long continued sterile state in the tissues when exposed to pyrazinamide and isoniazid is a highly specific drug-microbe phenomenon in which host participation is not critical. Although it is the pyrazinamide that possesses the sterilizing type of action, the role of the isoniazid is specific and essential. The isoniazid serves to convert a phenomenon that occurs irregularly with pyrazinamide alone into one that occurs with a high degree of uniformity. The observations suggest a competition between isoniazid and the pyrazinamide (or its parent nicotinamide) for a site or entrance in or on the tubercle bacilli and for sterilization, the isoniazid apparently must reach the site first. The rare failures to attain complete sterilization, appear to depend on the emergence of pyrazinamide-resistance which prevents the necessary dependent action of the two drugs. Populations already in the sterile state are nevertheless subject to a continued drug influence. Whether this represents a direct action on the sterile bacilli or an indirect effect produced by making the environment hostile to microbial revival, cannot be determined from the present observations.