miR-199a-5p suppresses epithelial-mesenchymal-transition in anaplastic thyroid carcinoma cells via targeting Snail signals (Retracted article. See vol. 34, pg. 697, 2022)
miR-199a-5p suppresses epithelial-mesenchymal-transition in anaplastic thyroid carcinoma cells via targeting Snail signals (Retracted article. See vol. 34, pg. 697, 2022)
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DOI：
10.3233/cbm-201518
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发表时间：
2020-01-01
影响因子：
3.1
通讯作者：
Chen, Dong
中科院分区：
文献类型：
--
作者：
Hao, Fengyun;Bi, Ya-Nan;Chen, Dong
MicroRNAs（miRNAs）在甲状腺未分化癌（ATC）的发生发展中起重要作用。先前报道miR-199 a-5 p在各种类型的癌症中充当肿瘤抑制因子或oncomiRNA。然而，其在ATC中的准确表达、功能和机制尚不清楚。在这里，我们发现miR-199 a-5 p在ATC组织中与邻近的非癌组织相比显著下调。过表达miR-199 a-5 p可显著抑制ATC细胞的体外迁移、侵袭和体内肺转移。重要的是，miR-199 a-5 p通过靶向Snail在体外和体内抑制上皮-间充质转化（EMT）。综上所述，本研究揭示了miR-199 a-5 p对ATC细胞中的EMT进展至关重要。靶向该通路可能成为抑制ATC转移的新途径。
MicroRNAs (miRNAs) have been validated to play prominent roles in the occurrence and development of anaplastic thyroid carcinoma (ATC). miR-199a-5p was previously reported to act as a tumor suppressor or oncomiRNA in various types of cancer. However, its accurate expression, function, and mechanism in ATC remain unclear. Here, we find that miR-199a-5p is significantly downregulated in ATC tissues compared with adjacent non-cancerous tissues. Overexpression of miR-199a-5p significantly inhibits migration and invasion of ATC cells in vitro, and lung metastasis in vivo. Importantly, miR-199a-5p suppresses epithelial-mesenchymal transition (EMT) both in vitro and in vivo by targeting Snail. Taken together, this study reveals that miR-199a-5p is critical to the EMT progression in ATC cells. Targeting the pathway described here may be a novel approach for inhibiting metastasis of ATC.