PERMANENT COVERAGE OF LARGE BURN WOUNDS WITH AUTOLOGOUS CULTURED HUMAN EPITHELIUM
PERMANENT COVERAGE OF LARGE BURN WOUNDS WITH AUTOLOGOUS CULTURED HUMAN EPITHELIUM
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DOI：
10.1056/nejm198408163110706
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发表时间：
1984-01-01
影响因子：
158.5
通讯作者：
GREEN, H
中科院分区：
文献类型：
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作者：
GALLICO, GG;OCONNOR, NE;GREEN, H
当烧伤范围很广，从剩余的供皮区获得的皮肤移植物不足以覆盖创面时，必须寻找新的自体移植物来源。从一个小的皮肤活检样品中提取的人表皮细胞可以培养成足以覆盖整个体表的连贯的上皮层。2当将这种上皮细胞应用于无胸腺小鼠的伤口时，它产生了人类表皮。3将自体培养的上皮细胞置于成人1和儿童5的小烧伤伤口上，产生了一个永久性的表皮，类似于断层皮肤移植。我们在这里报告说，在两个孩子谁持续.
WHEN burns are so extensive that skin grafts obtainable from remaining donor sites are insufficient to provide wound coverage, a new source of autograft must be found. Human epidermal cells from a small skin-biopsy sample can be cultured to produce coherent epithelial sheets sufficient to cover the entire body surface.1,2When this epithelium was applied to wounds on athymic mice it generated a human epidermis.3Autologous cultured epithelium placed on small burn wounds in adults'1and children5adhered and generated a permanent epidermis similar to that resulting from split-thickness skin grafts. We report here that in two children who sustained . . .