Somatosensory responses in a human motor cortex.
Somatosensory responses in a human motor cortex.
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人类运动皮层的体感反应。
DOI：
10.1152/jn.00368.2012
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发表时间：
2013
影响因子：
2.5
通讯作者：
Hochberg,LeighR
中科院分区：
文献类型：
--
作者：
Shaikhouni,Ammar;Donoghue,JohnP;Hochberg,LeighR
体细胞感觉信号为运动皮层提供了主要的反馈来源。中风或受伤后体感系统的变化可能会深刻影响正在开发的脑机接口（BCI），以根据运动皮层活动模式创建新的输出信号。我们有独特的机会来研究长期脑干中风但感觉通路完好的人初级运动皮层的手/臂区域神经元对被动关节操作的反应。正如之前对完整灵长类动物的研究所预测的那样，神经元会对对侧肩部、肘部或腕部的被动操作做出反应。因此，尽管手臂/手部瘫痪和皮质输出受损，但基本特性和组织得以保留。尝试的手臂动作也会参与相同的神经元。这些结果表明，在皮层输出中断数年后，完整的感觉通路仍然有可能影响初级运动皮层的放电率，并可能有助于脑机接口应用的运动意图的在线解码。
Somatic sensory signals provide a major source of feedback to motor cortex. Changes in somatosensory systems after stroke or injury could profoundly influence brain computer interfaces (BCI) being developed to create new output signals from motor cortex activity patterns. We had the unique opportunity to study the responses of hand/arm area neurons in primary motor cortex to passive joint manipulation in a person with a long-standing brain stem stroke but intact sensory pathways. Neurons responded to passive manipulation of the contralateral shoulder, elbow, or wrist as predicted from prior studies of intact primates. Thus fundamental properties and organization were preserved despite arm/hand paralysis and damage to cortical outputs. The same neurons were engaged by attempted arm actions. These results indicate that intact sensory pathways retain the potential to influence primary motor cortex firing rates years after cortical outputs are interrupted and may contribute to online decoding of motor intentions for BCI applications.